Methods of treating and/or preventing nail conditions and/or improving appearance of nails

A nail and methyl ethyl ketone technology, used in manicure, skin diseases, pharmaceutical formulations, etc., can solve problems such as slow treatment methods, no effect on improving the appearance of nails, and aggravating activities.

Pending Publication Date: 2022-08-02
CHESSON LAB ASSOC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Treatment of nail conditions can include limiting external factors, such as activities that may cause or exacerbate the condition, which may not be appropriate for the individual
Other treatments may include treating a possible underlying condition, but such treatments may be slow and may not be effective in improving the appearance of the nails

Method used

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  • Methods of treating and/or preventing nail conditions and/or improving appearance of nails
  • Methods of treating and/or preventing nail conditions and/or improving appearance of nails
  • Methods of treating and/or preventing nail conditions and/or improving appearance of nails

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0083] According to some embodiments of the present invention, the polyiso(thio)cyanate is included in the poly(urea-urethane) polymer. Any suitable polyiso(thio)cyanate may be included in the composition including, for example, aliphatic polyisocyanates, aromatic polyisocyanates, cycloaliphatic polyisocyanates, polyisocyanate heterocycles and heteroaromatic polyisocyanates. Exemplary polyisocyanates include, polyaryl polyisocyanates as defined in US Patent No. 2,683,730; toluene diisocyanate (also known as "TDI"); triphenylmethane-4,4'4" triisocyanate, benzene-1,3,5-triisocyanate; toluene-2,4,6-triisocyanate; diphenyl-2,4,4'-triisocyanate; hexamethylene diisocyanate; xylylene Diisocyanate; Chlorene diisocyanate; Diphenylmethane-4,4'-diisocyanate; Naphthalene-1,5-diisocyanate; Xylene-α,α'diisothiocyanate; 3,3'-diisocyanate Methyl-4,4'-biphenylene diisocyanate; 3-3'dimethoxy-4,4'-biphenylene diisocyanate; 2',3,3'-dimethyl-4, 4'-biphenylene diisocyanate; 5,5'-tetramethyl-4,4'...

Embodiment 1

[0134] Exemplary compositions of the present invention are provided below. The amounts of all components are determined in terms of stoichiometric equilibrium volumetric contents, expressed in milliliters. Liquid thermoset, hydrophobic, elastic, non-toxic polymer solution compositions are prepared by adding reactants in the sequence given by the formula below. The solution was continuously agitated and mixed at 20 revolutions per minute during the continuous addition of the ingredients, and 15 to 20 minutes after the addition of the last components. These parameters of the agitation mixing process, in terms of revolutions and time, are optimal to obtain maximum continuous reactivity of the ingredients during blending. The sequential mixing process was performed at ambient conditions of 70-80°F, approximately 750-760 mm Hg, and 50-65% relative humidity.

[0135] Therapeutic Device Formulation #1 Job Identifier: PMS-P-1000

[0136]

[0137] Therapeutic Device Formulati...

Embodiment 2

[0153]For each of Examples 2-12, the reagents were added in the order indicated and stirred for about 5 minutes between reagent additions. The MDI was added last and was added slowly with stirring. The reactants were kept at room temperature and about 70°C throughout the reaction. After the isocyanate addition was complete, the reaction was stirred for about 10 minutes and then transferred to a sample tank for storage using high performance liquid chromatography (HPLC), gel permeation chromatography (GPC), gel permeation chromatography with multi-angle light prior to storage Scattering Detection (GPC-MALS), Nuclear Magnetic Resonance (NMR) Spectroscopy Fourier Transform Infrared (FT-IR Combination) Spectroscopy was performed to determine molecular weight, confirm chemical structure, and confirm reaction completion. Fourier transform infrared (FT-IR) spectroscopy was performed using high performance liquid chromatography (HPLC), gel permeation chromatography (GPC), gel permeat...

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Abstract

Systems and / or methods for treating and / or preventing nail conditions are disclosed. In addition, the invention also discloses a system and / or a method for improving the appearance of a nail. A preferred embodiment of the invention includes a method of treating and / or preventing a nail condition in a subject comprising topically applying a composition comprising a poly (urea-urethane) polymer and / or a poly (urea-urethane) prepolymer to a nail of the subject, thereby treating and / or preventing the nail condition.

Description

technical field [0001] The present invention generally relates to a system and / or method for treating and / or preventing nail disorders, and / or a system and / or method for improving the appearance of nails. Background technique [0002] Nail disorder is a medical disorder that tends to be embarrassing and may make individuals feel coy because of the appearance of the nails. Treatment of a nail disorder may include limiting external factors, such as activities that may cause or exacerbate the disorder, which may not be appropriate for the individual. Other treatments may include treating a possible underlying condition, but such treatments may be slow and may not be effective in improving the appearance of the nails. [0003] The present invention addresses the deficiencies of the prior art by providing systems and / or methods for treating and / or preventing nail disorders, and / or by providing systems and / or methods for improving the appearance of nails. SUMMARY OF THE INVENTI...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/573A61K45/00A61K47/34A61P17/00A61P17/06A61P31/02
CPCA61K8/86A61K31/785A61K8/87A61K8/84A61K47/34C09D175/02C09D175/04A61Q3/02
Inventor 兰斯·L·斯维克斯科特·E·纳维尔杰瑞·S·切逊
Owner CHESSON LAB ASSOC
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