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Methods and systems for using and controlling higher dose rate ionizing radiation over short time intervals

A technology of ionizing radiation and control systems, applied in the field of methods and systems, capable of solving problems such as excessive dose delivery errors

Pending Publication Date: 2022-08-02
INTRAOP MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because FLASH therapy delivers significant doses in very short time frames, slow sensing techniques and overall control responses found on conventional medical radiation systems can lead to excessive errors in dose delivery

Method used

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  • Methods and systems for using and controlling higher dose rate ionizing radiation over short time intervals
  • Methods and systems for using and controlling higher dose rate ionizing radiation over short time intervals
  • Methods and systems for using and controlling higher dose rate ionizing radiation over short time intervals

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0213] Table 1:

[0214]

[0215]

[0216] The data in Table 1 show that the MOBETRON electron beam machine is operable to generate a FLASH dose rate at the 6MeV energy level, between the FLASH output (Gy / s) and the location of the flattening filter and the measured FLASH output along the beam path The distance (cm) is correlated (inverse square law). The data also show the effect of field size on output when MOBETRON's beam parameters are adjusted to operate at the FLASH dose rate. In this experiment, for the FLASH dose rate, the MOBETRON pulse width was set to 4.0 μs and the pulse rate was set to 45 pulses per second (PPS). This output is compared to a standard (non-FLASH) MOBETRON output of 10Gy / min. (1.6μs pulse width and 30PPS). Measurements were performed in air using a Marcus chamber. Distances are measured from standard MOBETRON treatment distances with the applicator in place.

example 2

[0218] Table 2:

[0219]

[0220]

[0221]The data in Table 2 were obtained in the same manner as in Table 1, but the MOBETRON was operated at 9 MeV. The data in Table 2 lead to the same conclusion that the MOBETRON electron beam machine is operable to generate FLASH dose rate at 9MeV energy level, FLASH output (Gy / s) with flattening filter and measured FLASH output along the beam path The distance (cm) between the positions is correlated (inverse square law).

example 3

[0223] MOBETRON is operated to determine whether the dose per pulse is sufficiently uniform that terminating in a partial pulse will achieve accurate dose delivery. The MOBETRON was run at a nominal dose rate of 30 Gy / s, as this was the maximum dose rate that did not saturate the electronics of the dosimetry system used in the experiments. Figure 12 and Table 3 below show the results for 1, 2, 5 and 10 pulses at 6 MeV, respectively. The pulse width was 3.7 μs (microseconds), and the gate voltage was 6 volts at 6 MeV.

[0224] table 3:

[0225]

[0226]

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Abstract

The present invention provides strategies for using and controlling the delivery of ionizing radiation for therapy and industrial irradiation therapy. The invention uses partial pulse control, component selection, and / or component configuration strategies in order to accurately monitor and terminate illumination. These strategies are particularly useful for controlling administration at high dose rates and short standards associated with FLASH techniques.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims US Provisional Patent Application No. 62 / 900,505, filed September 14, 2019, entitled "CONTROL AND OPERATION OF ANELECTRON BEAM AT FLASH ENERGY LEVELS," and entitled "METHODS," filed March 6, 2020 AND SYSTEMS FOR USING AND CONTROLLING HIGHERDOSE RATE IONIZING RADIATION IN SHORT TIME INTERVALS", the benefit of US Provisional Patent Application No. 62 / 986,104, the disclosure of which is incorporated herein by reference in its entirety for all purposes. technical field [0003] The present invention relates to the field of methods and systems for therapeutic and industrial treatment using ionizing radiation. More particularly, the present invention relates to methods and systems in which ionizing radiation is controlled using a partial pulse strategy to deliver an accurate dose even when the dose is delivered in short time intervals resulting in the use of higher dose rates. Background technique ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10G01T1/29
CPCA61N5/1077A61N5/1048A61N5/1071A23L3/263A61N5/1067A23B4/015A61N2005/1089
Inventor 肯尼斯·W·布鲁克斯詹姆斯·A·尼尔逊德里克·T·德西奥利克里斯托弗·J·佩特尼唐纳德·A·戈尔
Owner INTRAOP MEDICAL