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Preparation method and application of abietane diterpenes in schizonepeta bracteata

A technology of Schizonepeta and petroleum ether, which is applied in the field of preparation of abietane diterpenes in Schizonepetae, can solve the problems of few research reports on Schizonepeta and achieve the effect of inhibiting inflammation

Pending Publication Date: 2022-08-05
新疆维吾尔自治区中药民族药研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Schizonepeta maculatum is widely used among the people, there are few domestic and foreign research reports on Schizonepeta maculatum

Method used

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  • Preparation method and application of abietane diterpenes in schizonepeta bracteata
  • Preparation method and application of abietane diterpenes in schizonepeta bracteata
  • Preparation method and application of abietane diterpenes in schizonepeta bracteata

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Embodiment 1

[0030] Embodiment 1: The Nepetabrate J, the chemical structural formula is

[0031]

Embodiment 2

[0032] Embodiment 2: As an optimization of the above-mentioned embodiment, it is obtained according to the following method: In the first step, the aerial part of Nepeta buds is pulverized and sieved, and ethanol is added. Under the condition of 60 ° C, heating and refluxing extraction for 3 times, each time for 1 hour to 3 hours, combining the reflux extracts and recovering and concentrating under reduced pressure to obtain the total extract of Nepeta spp.; After the extract is dispersed with water into a suspension, it is extracted with petroleum ether, chloroform and ethyl acetate in turn, and the extract is concentrated to obtain the extract of each part; in the third step, the extract of the petroleum ether part is eluted with a gradient of silica gel column chromatography After separation, 8 fractions are obtained, wherein, the gradient eluent of silica gel column chromatography includes petroleum ether and ethyl acetate, and the volume ratio of petroleum ether and ethyl ...

Embodiment 3

[0033] Embodiment 3: As the optimization of the above-mentioned embodiment, in the first step, 30L of ethanol is added to the aerial part of every 6kg of Nepeta bud.

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Abstract

The invention relates to the technical field of separation and purification of overground parts of schizonepeta bracteata, in particular to Nepetatide J, a preparation method thereof and application of the Nepetatide J in preparation of drugs for preventing inflammation. The invention discloses the Neepetarate J for the first time, and the Neepetarate J disclosed by the invention has a relatively strong anti-inflammatory effect on RAW 264.7 cells stimulated by lipopolysaccharide (LPS), and can remarkably resist inflammation and inhibit inflammation, so that the Neepetarate J can be applied to preparation of inflammation prevention medicines and anti-inflammatory medicines.

Description

technical field [0001] The invention relates to the technical field of separation and purification of aerial parts of Nepeta bud, and relates to a preparation method and application of rosinane diterpene in Nepeta bud, wherein, the rosin diterpene in Nepeta bud is the one obtained from Nepetabrate J. Abbreviation. Background technique [0002] Nepeta bractata is the dry whole grass of Nepeta bracteata Benth. of Labiatae, and the Uyghur name is also "Zufa". In ancient books such as Baidiyi and Maikesan Aidiwei, the dried whole herb is used as medicine. Mainly distributed in Pakistan, Iran, Nepal and other countries. "Uyghur Medicine Records" records that the whole plant of Nepeta Nepeta has the functions of relieving cough and relieving asthma, clearing heat and removing dampness, and is used to treat bronchitis, cough and asthma, cold and fever embolism. Although Nepeta sphaeroides is widely used in the folk, there are few research reports on Nepeta spp. at home and abroa...

Claims

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Application Information

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IPC IPC(8): C07C69/757C07C67/48C07C67/56C07C67/58A61P29/00
CPCC07C69/757A61P29/00C07C2603/26Y02A50/30
Inventor 石磊岭马国需魏鸿雁樊丛照孙照翠刘红玉李小万宋海龙
Owner 新疆维吾尔自治区中药民族药研究所
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