Prophylactic and/or therapeutic agent for chronic prostatitis/chronic pelvic pain syndrome
A technology for chronic prostatitis and pelvic pain, applied in the direction of drug combinations, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as the relationship between chronic prostatitis that has not been reported
Pending Publication Date: 2022-08-05
NIPPON SHINYAKU CO LTD
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Problems solved by technology
[0006] However, so far, the relationship between chronic prostatitis and the mPGES-1 pathway has not been reported
Method used
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[0438] Hereinafter, the present invention will be described in more detail with reference to Reference Examples, Examples, Test Examples, and Formulation Examples, but the present invention is not limited thereto.
[0439] The test compounds used in Test Examples 1 and 2 are as follows.
[0440] The compounds used in Test Examples 1 and 2 were prepared and used according to the description in Examples 1 to 249 of WO2013 / 024898. The activity data of the compounds used in Test Examples 1 and 2 are shown in Tables 1 to 17 of WO2013 / 024898.
preparation example 1
[0523] Tablet (Oral tablet)
[0524] In prescription 1 tablet 80mg
[0525]
[0526] The mixed powder of this ratio is compressed and molded by a usual method to prepare an oral tablet.
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The present invention relates to a prophylactic and / or therapeutic agent for chronic prostatitis / chronic pelvic pain syndrome, which contains an mPGES-1 inhibitor as an active ingredient.
Description
technical field [0001] The present invention relates to a preventive and / or therapeutic agent for chronic prostatitis / chronic pelvic pain syndrome containing an mPGES-1 inhibitor as an active ingredient. Background technique [0002] Prostatitis is classified into 4 categories (acute bacterial prostatitis, chronic bacterial prostatitis, chronic prostatitis / chronic pelvic pain syndrome, asymptomatic inflammatory prostatitis) by the US NIH (Non-Patent Document 1). Category I is acute bacterial prostatitis with systemic symptoms such as urination symptoms, pain, and fever due to bacterial infection. Category II is chronic bacterial prostatitis, which is a chronic form of category I, and is confirmed to have symptoms of recurrent bacterial infection. Category III is chronic prostatitis / chronic pelvic pain syndrome, and is classified as a disease with urination symptoms such as pain / discomfort in the pelvic area such as the perineum, testicles, penis, and lower abdomen, residual...
Claims
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IPC IPC(8): A61K45/00A61K31/343A61K31/416A61K31/4184A61K31/423A61P13/08
CPCA61K31/343A61P13/08A61K31/423A61K31/416A61K31/4184A61K45/06A61K31/454A61K31/506A61K45/00A61P29/00
Inventor 冈本贤栗田麻希山口浩史
Owner NIPPON SHINYAKU CO LTD