70 results about "Pelvic pain syndrome" patented technology

The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I)

in which the groups Q¹-Q⁴, Ar, and R¹-R⁷ are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.

The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e g inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome.

The present invention relates to the use of an anti-NGF antibody in the treatment or prevention of pain and/or a lower urinary tract symptom (LUTS) associated with chronic prostatitis and/or chronic pelvic pain syndrome.

The present invention is directed to methods of treating a chronic pelvic pain syndrome comprising the step of administering to a subject suffering from prostatis a chorionic gonadotropin or a pharmaceutically active fragment or derivative thereof in an amount effective to alleviate one or more symptoms of a chronic pelvic pain syndrome.

The present invention relates to the association between detecting and quantifying the presence of macrophage migration inhibitory factor (MIF) in urine, bladder and prostate tissues for the purpose of diagnosis and prognosis of urological inflammatory. In addition, methods to inactivate MIF activity by use of antibodies or specific MIF inhibitors can be used to treat these diseases. For instance, such diseases as chronic pelvic pain syndrome, non-bacterial prostatitis, and interstitial cystitis may be mediated by MIF release. Periodic assays for MIF could be conducted for a patient to determine if the patient's MIF urine levels are high or increasing. In addition, intravesical MIF antibodies or other MIF-specific inhibitors would reduce or ameliorate these pelvic diseases.

[Problems] A compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases is provided.

[Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that a piperazine-1-carboxylate compound, in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl or the like binds to the 4-position of the piperazine, has an excellent FAAH inhibitory activity and further has an action to increase the effective bladder capacity, an action to ameliorate sleep disorders, an anti-diuretic action, and an analgesic activity on lower urinary tract pain including bladder pain and the like, thereby completed the present invention. The carbamate compound of the present invention has an excellent FAAH inhibitory activity and can be used as an agent for preventing and/or treating FAAH-related diseases, particularly nocturia, interstitial cystitis, painful bladder syndrome, or chronic non-bacterial prostatitis/chronic pelvic pain syndrome.

The present invention relates to the use of TNF-α for the treatment of a pain and/or a urinary tract symptom(s) associated with Cronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS).

Compounds of formula (I),

or a pharmaceutically acceptable derivative thereof, wherein R¹ and R³ independently represent H, C_1-6alkyl, C_3-8cycloalkyl, or halogen; R² represents C_1-6alkyl, CF₃ or aryl; a represents 1 or 2; R⁴, R⁵, R⁷ and R⁸ independently represent H, C_1-6alkyl, C_1-6alkyloxy, CN or halogen, or R⁴ and R⁵, or R⁷ and R⁸, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH₂ or O; R⁶ represents H, CN or halo provided that, when X represents N, R⁶ is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.

The present invention provides biomarkers of chronic pelvic pain syndrome for use in diagnosis, drug screening, therapy monitoring, research and therapeutic applications. In particular, the present invention provides MCP-1 and MIP-1α as biomarkers of chronic pelvic pain syndrome.

The invention provides a treatment head and device for chronic pelvic pain syndromes. The treatment head for the chronic pelvic pain syndromes comprises a disposable coupling membrane, an electromagnetic cup, an arc-shaped vibration diaphragm component, an arc-shaped emitter, a metal coil and a seat sleeve component, the disposable coupling membrane is arranged on the electromagnetic cup, the arc-shaped vibration diaphragm component is arranged between the electromagnetic cup and the metal coil, the metal coil is attached to the inner wall of the arc-shaped emitter, and the arc-shaped emitteris arranged on the seat sleeve component, wherein the incident surface energy flow density of the arc-shaped emitter within a preset vertical height range is equal to the exit surface energy flow density. The generated shock waves converge into a stable energy space at a fixed distance from the generator end opening of the treatment head, and then the effective area covers an entire prostate to realize shock wave treatment; and the treatment head is non-invasive and safe and has no side effects in the process, the operation is simple, the treatment is fast, the manpower and time expenses are small, and the treatment costs are low.

The invention relates to a traditional Chinese medicine for treating dampness and hotness obstruction type chronic pelvic pain syndrome and aims to effectively solve the problems of poor treatment effect on the dampness and hotness obstruction type chronic pelvic pain syndrome and difficulty in fundamental solving of diseases. According to the technical scheme, the traditional Chinese medicine is prepared from the following raw medicines: 28-32g of hedyotis diffusa, 18-22g of dandelion, 18-22g of dahurian patrinia herb, 28-32g of salvia miltiorrhiza, 14-16g of paeonia veitchii, 5-7g of leech, 14-16g of tree peony root-bark, 2.5-3.5g of amber, 23-27g of crude jobstears seed and 14-16g of plantain seed. A method comprises the following steps: mixing the raw medicines together; putting the raw medicines into a container; immersing the raw medicines in 700-900ml of water for 25-35 minutes; decocting the raw medicines over high heat until the water is boiled, and decocting the raw medicines for 18-22 minutes over soft fire; performing filtration, and preserving filtrate to obtain the traditional Chinese medicine. The traditional Chinese medicine is prepared from the purely natural raw medicines; all medicines are organically matched, support one another, and are reasonably prepared; the raw materials are rich; the method is simple; the traditional Chinese medicine is convenient to take, good in curative effect and low in cost, and is an innovation of a medicine for treating the dampness and hotness obstruction type chronic pelvic pain syndrome.