Carbamate compound or salt thereof

A technology of compounds and base esters, applied in the field of carbamate compounds or their salts, which can solve the problems of insufficient effect in patients with nocturia
CN102209718AInactive Publication Date: 2011-10-05ASTELLAS PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2011-10-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed is a compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases. Extensive studies have been made on compounds having an FAAH-inhibiting activity, and it is confirmed that a piperazine-1-carboxylate compound having a benzimidazol-2-ylcarbonyl, a benzofuran-2-ylcarbonyl or the like bound to position-4 in the piperazine moiety has an excellent FAAH-inhibiting activity and has an activity to increase the effective bladder capacity, an activity to ameliorate sleep disorder, an anti-diuretic activity and an analgesic activity on lower urinary tract pain including bladder pain. The carbamate compound has an excellent FAAH-inhibiting activity and can be used as a prophylactic and / or therapeutic agent for FAAH-related diseases, particularly nycturia, interstitial cystitis, painful bladder syndrome or chronic non-bacterial prostatitis / chronic pelvic pain syndrome.
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Description

technical field

[0001] The present invention relates to a carbamate compound or a salt thereof useful as an active ingredient of a pharmaceutical composition, particularly a pharmaceutical composition for treating FAAH-related diseases. Background technique

[0002] Frequent urination can be broadly classified into diurnal frequency and nocturia (Journal of the Japanese Society of Urinary Function, Vol. 14, 2003). Daytime frequent urination refers to a self-reported symptom of a patient who urinates excessively during the day, and the number of daytime frequent urination (for example, more than 8 times) is sometimes specified for convenience. On the other hand, nocturia refers to "complaints of having to wake up at night to urinate one or more times" and is defined as a new disease (International Continence Society: ICS, 2002). The occurrence of nocturia is considered to be related to various causes, and the main factors include nocturnal polyuria, decreased nocturnal bladd...

Claims

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