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Chicken methylation clock

A chicken methylation and methylation technology, applied in the field of determining the chronological age and epigenetic age of chickens, can solve the problems of unexplored evolutionary conservation

Pending Publication Date: 2022-08-05
EVONIK OPERATIONS GMBH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Evolutionary conservation of LMRs other than mammals remains unexplored

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Embodiment Construction

[0039] The elements of the present invention will be described below. These elements are listed with specific embodiments; however, it should be understood that they may be combined in any manner and in any number to create additional embodiments. The various described examples and preferred embodiments should not be construed to limit the invention to only the explicitly described embodiments. This description should be understood to support and encompass embodiments formed by the combination of two or more expressly described embodiments or one or more expressly described embodiments in combination with any number of the disclosed and / or preferred elements. Furthermore, unless context dictates otherwise, all permutations and combinations of elements described in this application should be considered as disclosed by the specification of this application.

[0040] As used herein, the terms "[of the] invention," "according to the present invention," "according to the invention...

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Abstract

The invention provides a method for establishing a chicken methylation clock. The method comprises the following steps: (a) determining a methylation rate and reading coverage of a genome CpG site of an age-related training sample of a specific chicken tissue; (b) defining a group of CpG loci with reliable methylation rate in all the training samples in the step (a) by using a cutoff value; and (c) performing penalty regression by applying a penalty regression model and taking the methylation rate in the step (b) as input and the age related to the training sample as a dependent variable, a set of CpG loci having respective weighting factors and intercept of the linear model equation are obtained as parameters defining the chicken methylation clock.

Description

technical field [0001] The present invention relates to a method for determining the chronological and epigenetic age ("chicken methylation clock") of chickens. [0002] Background of the Invention [0003] Chicken (Gallus gallus) is an important non-mammalian vertebrate model organism and an important source of commercially produced meat and eggs. Therefore, the factors affecting chicken growth, pathogen resistance and meat quality are of considerable scientific and economic interest. Extensive genome-wide association studies have been performed to elucidate the underlying genetic framework. Epigenetic modifications provide an important complement and expansion of genetic variation, but are relatively underexplored in chickens. [0004] Animal methylomes can be highly diverse, ranging from certain insect genomes with sparse methylation patterns and only tens of thousands of methylation markers to dense methylation patterns and tens of millions of methylation markers Marke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/112C12Q2600/118C12Q2600/154C12Q1/6888C12Q2600/124C12Q2537/165
Inventor F·博埃尔F·吕科R·惠兰A·卡佩尔E·I·伊圭F·蒂曼G·拉达茨
Owner EVONIK OPERATIONS GMBH
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