IgG epitope peptide of whey allergen beta-lactoglobulin

A technology of epitope peptides and allergens, which is applied in the field of immunology, can solve the problems of less reports on epitope localization of milk whey allergens

Pending Publication Date: 2022-08-09
AUSNUTRIA DAIRY CHINA
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for identification of beta lactic acid antigens from cow's milk by comparing them with those found on other species like humans or dogs (BSA). These differences can indicate an allergies caused due to different sources such as animal feedings or food ingredients used during production processes.

Problems solved by technology

This patented technical problem addressed in this patents relates to studying the relationship between different types of animal feedstuff ingredients like wheat germ meal flour, lamb stearbons, barley bean powder, oatmea albumina, alpha lactic aldehydes, tannoid compounds, chlorophyllanes, carboxymethyltrypsone soluble factor, histidase, tryptic enzymes, etc., while investigating various structural features related to these components.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • IgG epitope peptide of whey allergen beta-lactoglobulin
  • IgG epitope peptide of whey allergen beta-lactoglobulin
  • IgG epitope peptide of whey allergen beta-lactoglobulin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Construction of serum pools for patients with milk allergy

[0041] 1. Indirect ELISA to screen serum of patients with milk allergy

[0042] Allergy patient serum used in this study was donated by Peking Union Medical College Hospital. The level of sIgG against cow's milk protein in the serum of allergic patients was detected by ImmunoCAP, and the serum of infants and young children with cow's milk protein sIgG level greater than or equal to 0.35kUA / L and aged 0-3 years was selected for ELISA. Determination of anti-β-lactoglobulin specific immunoglobulin G (BLG-sIgG) in serum of patients with cow's milk allergy by indirect ELISA. Study on the linear epitope of ovomucoid IgE by ELISA method [D]. Tianjin Medical University, 2020: 11-16.).

[0043] The coating solution is 0.05mol / L carbonate buffer with pH 9.6. The washing solution, blocking solution, serum, secondary antibody, etc. are all diluted with 0.01M PBS buffer. The washing solution contains 0.05% (v / v) Twee...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of immunology, in particular to IgG epitope peptide of whey allergen beta-lactoglobulin. The invention provides an IgG binding epitope of beta-lactoglobulin, and the epitope aims at the epitope of specific cow milk whey allergen of Chinese population, and has great significance on the molecular mechanism of cow milk allergy, the screening of protease for guiding directional breaking of the epitope and the development of low-allergy whey protein products based on the epitope.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner AUSNUTRIA DAIRY CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap