Gatifloxacin gels for eye and its preparing method

Abstract

The invention discloses a gatifloxacin ophthalmic gel and a preparation method thereof, aiming at overcoming the defects of drug resistance caused by long-term use of the existing ear drops and many times of medication by patients, and providing a gatifloxacin ophthalmic gel eye gel. It is a medicine containing the following percentages by weight: 0.05%-0.4% of gatifloxacin, 0.5%-1.5% of carbomer, and 1%-2% of triethanolamine. The preparation steps are as follows: sprinkle carbomer on the surface of glycerin, grind and infiltrate, then grind with distilled water to make it fully swell; dissolve triethanolamine in distilled water, add supernatant and grind to make gel matrix (III); Add gatifloxacin to distilled water, stir to dissolve; then add propylene glycol and stir well to make a mixed solution (IV); slowly add the mixed solution (IV) to (III), add distilled water to the entire amount, and grind until uniform.

Description

technical field [0001] The invention relates to an externally used medicine for treating eye infections and a preparation method thereof, in particular to a slow-release eye gel for treating eye infections and a preparation method thereof. Background technique [0002] So far, there are few varieties of antibiotics for the treatment of eye infectious diseases, and the products are aging. The current clinical preferred antibiotics are compound preparations of ciprofloxacin hydrochloride, tobramycin and dexamethasone (trade name: Tobrex). The disadvantage of Tobrex is that the price is relatively expensive. In contrast, the price of ciprofloxacin hydrochloride eye drops is relatively low. However, ciprofloxacin hydrochloride eye drops are more irritating to the eyes and are difficult for patients to accept. Especially the long-term use of old antibiotic eye drops causes the increasing number of antibiotic-resistant bacteria, so the therapeutic effec...

AI Technical Summary

Problems solved by technology

Ophthalmic gels of drugs such as tropicamide, pilocarpine, chloramphenicol and betamethasone have been developed and applied abroad, but there is no report on the research of GFLX ophthalmic gel preparations