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Prepration process for biologic hemostatic sponge material

A hemostatic sponge and biological technology, which is applied in the field of preparation of medical biological hemostatic materials, can solve the problems of mechanical properties, antibacterial performance defects, complex hemostatic sponge production process, poor adhesion of wound tissue, etc., to achieve wide application value, good biophase capacitive, low cost effect

Inactive Publication Date: 2005-09-07
北京益而康生物工程有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a collagen and gelatin hemostatic sponge is used in the prior art, but the production process of the hemostatic sponge is complicated, the cost is high, the adhesion to the wound tissue is poor, and there are still defects in aspects such as mechanical properties and antibacterial properties.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve chitosan with a deacetylation degree of 50% and a molecular weight of 10,000 Daltons in 0.1M hydrochloric acid solution to make a 1% chitosan solution, static defoaming, subpackaging in containers, and freeze-drying , to make a sponge layer with a thickness of 1 mm; after soaking with ammonia / ethanol (7:3) for 5 minutes, rinse with distilled water. Then lyophilized, Co 60 Disinfect and spare.

Embodiment 2

[0024] Dissolve chitosan with a deacetylation degree of 70% and a molecular weight of 50,000 Daltons in 1% acetic acid, vacuum defoam, pack in containers, and freeze-dry to form a sponge layer with a thickness of 2 mm. After soaking for 15 minutes, rinse with distilled water. Then lyophilized, Co 60 Disinfect and spare.

[0025] In use, a small amount of 1% chitosan acetic acid (adjusting the pH value of the solution to about 5 with sodium bicarbonate solution) can be used to smear the chitosan sponge attachment surface to enhance the adhesion and hemostatic effect of the chitosan sponge.

Embodiment 3

[0027] Dissolve chitin with a deacetylation degree of 20% and a molecular weight of 100,000 Daltons in a mixed solvent of trichloroacetic acid / chlorinated hydrocarbon (3:1) to make a chitin solution with a concentration of 1%, and remove the air bubbles , subpackage in the container, then add the fibrinogen of 0.5% and the sorbitol of 1% by weight, lyophilize, make the sponge layer of 3mm thick, after soaking in ammoniacal liquor / methanol (7: 1) for 5 minutes, distilled water Rinse well, then freeze-dry, Co 60 Disinfect and spare.

[0028] During use, the sponge layer can be directly attached to the wound, and the sponge can be pressed with tweezers.

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Abstract

A method of producing biological hemostasis spongy material. It comprises: taking chitosan / chitin as the main raw material, preparing the solution, defoaming and putting into a container and freeze-drying, forming a spongy layer with the thickness of 1-10mm; soaking with ammonia, ammonia / alcohol, ammonia / acetone, ammonia / methanol, washing with distilled water, freeze-drying and disinfecting. The prepared hemostasis spongy material has abilities of stanching bleeding and promoting tissue rehabilitation.

Description

technical field [0001] The invention relates to a preparation method of a medical biological hemostatic material, which belongs to the technical field of medical material preparation. Background technique [0002] Chitin, also known as chitosan, chitin, chitin, chitin, shell protein, etc., is a linear amino polysaccharide that maintains and protects the bodies of crustaceans and microorganisms and is insoluble in water, alkali and conventional solvents. Widely present in the wings or shells of arthropods (spiders, crustaceans) and in the cell walls of fungi and algae (Chen Tian, ​​Yan Jun, Xu Rongnan, Xia Yan. Journal of Biomedical Engineering, 1989; 6 (1) : 60.), the annual biosynthesis is nearly one billion tons, only 10% to 30% of the crustacean waste after the processing of aquatic products such as crabs and shrimps. It is a natural resource with potential value and yet to be developed. Acid-soluble chitosan (Chitosan) is a deacetylated compound of chitin, a derivative...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28
Inventor 王小红刘军朵
Owner 北京益而康生物工程有限公司
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