Process and apparatus for automatically synthesizing carbon-11-methyl iodide
A technology of methyl iodide and synthetic carbon, which is applied in the preparation of halogenated hydrocarbons, chemical instruments and methods, organic chemistry, etc., can solve the problems of inability to realize heating and cooling, easy leakage of radioactive gases, inconvenient automatic liquid addition, etc., to achieve Simplify equipment, facilitate automatic control, and reduce losses
Inactive Publication Date: 2006-02-08
于生民 +2
View PDF0 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0025] The disadvantage of this method is that the radioactive gas is easy to leak and the yield is low
[0026] At present, in order to increase the yield and output, most of the laboratories have adopted the first method. Siemens has realized the automation of this method, but the yield after automation is not high, about 20-30%.
Therefore, Iwata concentrated the step-by-step double reaction tubes on one reaction tube, but there are two disadvantages: one is that HI is a highly corrosive liquid, which is not convenient for automatic liquid addition, so the improved system is manual operation; the other is to use The air heat method cannot realize the integration of heating and cooling
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0037] The present invention will be described in detail below in conjunction with specific examples.
[0038] The automatic synthesis of carbon-11 methyl iodide process consists of the following steps:
[0039] 1. The reaction tube is filled with 0.2ml lithium aluminum hydride / tetrahydrofuran (THF) solution, the concentration of lithium aluminum hydride is 15mg / ml, and the reaction tube is cooled to about -5°C by compressed air;
[0040] Generally speaking, the lithium aluminum hydride / tetrahydrofuran (THF) solution contained in the reaction tube can be between 0.1 and 0.4ml, such as 0.1ml, 0.2ml, 0.3ml, or 0.4ml, and the concentration of lithium aluminum hydride 5-30mg / ml, usually 5mg / ml, 15mg / ml or 30mg / ml are optional concentrations, and the cooling of the reaction tube should generally be between 0°C and -5°C.
[0041] 2. After the bombardment of radioactive carbon-11 carbon dioxide produced by the accelerator is completed, it is carried by helium or argon gas and slowly...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| length | aaaaa | aaaaa |
| diameter | aaaaa | aaaaa |
| length | aaaaa | aaaaa |
Login to View More
Abstract
The present invention relates to the preparation of positive electron emitting medicine, and is especially the automatic preparation process and apparatus of carbon-11 iodomethane as the precursor of radiopharmaceutical for PET. The preparation process includes cooling reaction tube holding lithium-aluminum hydride / tetrahydrofuran solution with compressed air, conveying the accelerator generated carbon-11 CO2 with carrying He or Ar into the reaction tube while heating, cooling the reaction tube to room temperature, adding hydrogen iodide and re-heating while cooling the upper part of the reaction tube with compressed air, collecting produced carbon-11 iodomethane, and adsorbing un-reacted carbon-11 CO2 with Plus column. The said preparation process has fast speed and high efficiency. The simplified apparatus combines cooling with compressed air and heating with electric heating rod into one single tube and is suitable for automatic control.
Description
technical field [0001] The invention relates to the field of preparation of positron radiopharmaceuticals, in particular to an automatic synthesis process and equipment of carbon-11-methyl iodide, the precursor of radiopharmaceuticals used in positron tomography (PET) diagnosis. Background technique [0002] Carbon-11 iodomethane is an indispensable precursor for the methylation of positron drugs, which is used in the synthesis of 11 C-methionine, 11 C-choline, 11 C-Raclopride, 11 C-NMSP, 11 Methylation of positron drugs such as C-FMZ. At present, the synthesis methods of carbon-11 methyl iodide mainly contain the following types: [0003] (1) Reaction of C-11 methanol with HI [0004] The first step produces carbon-11 methanol: [0005] <chemistry num="001"> <chem file="200310115194_cml001.xml" / > < / chemistry> [0006] In the second step, carbon-11 methanol is evaporated to reflux in hydroiodic acid to generate carbon-11 methyl iodide: [0007]...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): C07C19/07C07C17/00
Inventor 张锦明田嘉禾周丹于生民
Owner 于生民