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Method for separating 6-gingerol from ginger

A gingerol and ginger technology, applied in the separation/purification of carbonyl compounds, organic chemistry, etc., can solve the problems of less research on the separation and extraction of active ingredients in ginger, no preparation of 6-gingerol monomer, etc., and achieve easy operation , high purity and simple process

Active Publication Date: 2006-03-29
北矿检测技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Regarding the research on ginger, there are currently many researches on the extraction of ginger oil and ginger oleoresin, the analysis of ginger oil components, and the pharmacology of ginger at home and abroad, but there are few studies on the separation and extraction of active ingredients in ginger. The obtained method is a mixture of multiple components, the best can only be separated from the homologue, as for the successful separation of a single component, according to the results of literature search, there is no 6-gingerol monomer so far. prepared report

Method used

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  • Method for separating 6-gingerol from ginger

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) prepare ginger oleoresin

[0028] Fresh ginger is dried at low temperature and crushed to 100 mesh, soaked in acetone to obtain ginger oleoresin;

[0029] (2) Coarse separation by silica gel column chromatography

[0030] Column chromatography specification: 15mm×300mm; stationary phase: silica gel for chromatography, 160-200 mesh. Taking ginger oleoresin as a sample, the amount of stationary phase: 13.0 g, and the sample size: 0.3 g. At a flow rate of 0.8mL / min, sequentially use the mobile phase  1 (n-hexane: ether) = 2: 3,  2 (n-hexane:ether)=1:4, methanol 35mL each to wash the chromatographic column. Collect  2 (n-hexane: ether)=1:4 fraction section;

[0031] (3) prepare crude gingerol

[0032] The above-mentioned fraction containing 6-gingerol was placed on a rotary evaporator to evaporate the solvent to obtain crude gingerol;

[0033] (4) liquid chromatography separation

[0034] The crude gingerol was dissolved in ether to prepare a sample solution...

Embodiment 2

[0041] (1) prepare ginger oleoresin

[0042] Fresh ginger is dried at low temperature and crushed to 100 mesh, soaked in acetone to obtain ginger oleoresin;

[0043] (2) Crude separation by silica gel column chromatography

[0044] Column chromatography specification: 20mm×400mm, stationary phase: silica gel for chromatography, 160-200 mesh. Taking ginger oleoresin as a sample, the amount of stationary phase: 35.0 g, and the sample size: 0.8 g. At a flow rate of 1.5mL / min, sequentially use the mobile phase  1 (n-hexane: ether) = 2: 3,  2 (N-Hexane: Ether) = 1:4, 110mL methanol each to wash the chromatographic column, collect  2 (n-hexane: ether)=1:4 distillate section;

[0045] (3) prepare crude gingerol

[0046] The above-mentioned fraction containing 6-gingerol was placed on a rotary evaporator to evaporate the solvent to obtain crude gingerol;

[0047] (4) liquid chromatography separation

[0048] Dissolve crude gingerol in ether to prepare a sample solution with...

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Abstract

The technological process of separating 6-gingerol from ginger includes the steps of: preparing ginger oleoresin, chromatographic separation with silica gel column, preparing coarse gingerol, liquid phase chromatographic separation, eliminating solvent, preparing pure 6-gingerol product, etc. The present invention has high 6-gingerol purity, simple operation, simple technological process and high separation efficiency.

Description

Technical field: [0001] The invention relates to the technical field of chemical industry and medicine, in particular to a method for separating 6-gingerol from ginger. Background technique: [0002] Traditional Chinese medicine believes that: Ginger is warm in nature, more pungent than warm, tends to go outside, can dispel wind and cold and relieve the outside, harmonize stomach qi and stop uh. Ginger can relieve cough and phlegm, treat nausea and vomiting, intestinal colic, etc. Eating ginger and its products can stimulate gastric mucosa, increase gastric juice secretion, and promote digestion and absorption of food. In Compendium of Materia Medica, it is said that ginger can be used for a long time to remove bad smell, clear the mind, and return to the five internal organs. Deficiency, bleeding, has the effect of expelling cold, warming and stopping, and detoxification. Modern scientific research shows that: Ginger has anti-platelet aggregation, boosts blood pressure an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/255C07C45/78
Inventor 李华昌符斌张雪红李万春汤淑芳
Owner 北矿检测技术股份有限公司
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