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Yew genus plant extract and its extraction method and application

A plant extract, yew technology, applied in chemical instruments and methods, plant raw materials, organic chemical methods, etc.

Active Publication Date: 2006-05-17
HARBIN HONGDOUSHAN TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of yew plant extract and its extraction method and its application, which not only solves the problem of the sustainable utilization of yew plants, but also improves the red bean quality under the premise of ensuring the curative effect. The utilization rate of Chinese fir plants has been increased from less than 2 / 10000 to more than 5 / 10000 for single-extracted paclitaxel

Method used

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  • Yew genus plant extract and its extraction method and application
  • Yew genus plant extract and its extraction method and application
  • Yew genus plant extract and its extraction method and application

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specific Embodiment approach 1

[0004] Embodiment 1: The Taxus genus plant extract in this embodiment is extracted from the branches and leaves of Taxus chinensis as raw materials, and it includes the following components: taxane diterpene compounds, total lignans, and total flavonoids. The taxane diterpene compound accounts for 18-68% of the total volume of the three components, the total lignans accounts for 14-61% of the total volume of the three components, and the total flavonoids accounts for 10-50% of the total volume of the three components. The taxane diterpene compounds include taxane, taxane B, 10-deacetyl baccatin III, 10-deacetyl taxane B and taxus pluvialis A; the total lignans Including hexetin; the total flavonoids include kaempferol and citrusin.

specific Embodiment approach 2

[0005] Specific embodiment two: the yew plant extract of the present embodiment is prepared according to the following steps: a, the branches and leaves of the yew genus medicinal material are extracted with an ethanol solvent with a volume concentration of 40 to 95% for 1 to 3 hours, Concentrate into the original extract; b, then add distilled water 30-80 times the weight of the original extract, dissolve the original extract at 60-80°C or under ultrasonic conditions, filter, centrifuge and precipitate after standing; c, use a volume concentration of 50-90% ethanol extracts the above-mentioned precipitate at 60-80°C or ultrasonic conditions, extracts three times, the amount of ethanol added each time is 5-15 times of the weight of the precipitate, filters and centrifuges after standing; d, merge Ethanol extract, add ethanol in the extract, be mixed with the solution that alcohol content is 20~40%, volume is 30~70 times of above-mentioned former extract; e, above-mentioned solu...

specific Embodiment approach 3

[0014] Specific Embodiment Three: The yew plant extract of this embodiment is used as an active ingredient of an anticancer drug for treating lung cancer, melanoma, and breast cancer.

[0015] Summary of pharmacodynamic experiments:

[0016] 1. Criteria for case selection:

[0017] 1. 40 cases of lung cancer, including 22 males and 18 females, the youngest is 29 years old, the oldest is 55 years old, the average age is 43 years old, the shortest course of disease is 2 years, and the longest is 10 years.

[0018] 2. 32 cases of breast cancer, all female, the youngest is 33 years old, the oldest is 54 years old, the average age is 44 years old, the shortest course of disease is 1 year, and the longest is 11 years.

[0019] 3. 25 cases of melanoma, including 20 males and 5 females, the youngest is 44 years old, the oldest is 62 years old, the average age is 50 years old, the shortest course of disease is 5 years, and the longest is 20 years.

[0020] 2. The diagnostic criteria ...

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Abstract

The invention relates to a plant extract of the genus Taxus, an extraction method of the extract and its application, and relates to a plant extract, its extraction process and its application as an anticancer drug. The yew plant extract of the present invention is extracted from the branches and leaves of the Chinese yew as raw materials, and includes the following components: taxane diterpene compounds, total lignans, and total flavonoids. After the branches and leaves of the yew are concentrated and extracted, they are concentrated under reduced pressure to obtain the yew plant extract, and the extract can be used as an active ingredient of an anticancer drug. The present invention is a drug made from the new medicinal parts of Taxus twigs and leaves. It contains various anti-cancer active ingredients and has the characteristics of high yield and low cost. Its anti-cancer effect is not lower than paclitaxel. It ensures the sustainable utilization of yew plants, and has extremely low side effects. Under the premise of ensuring the curative effect, the utilization rate is increased by more than 25 times.

Description

Technical field: [0001] The present invention relates to a plant extract and its extraction process and its application as an anticancer drug, in particular to an active ingredient of an anticancer drug extracted from branches and leaves trimmed from yew plants, its extraction process and its application as an anticancer drug. drug application. Background technique: [0002] The number of patients dying of cancer is increasing every year in our country, and cancer has become one of the diseases that seriously endanger human health in today's society. Paclitaxel extracted from the yew plant is used to treat cancer, and it has been proved to be effective in clinical practice. However, the extraction of paclitaxel mainly comes from the bark of the yew plant, and the content is extremely low, resulting in the death and extinction of the yew plant. CN1112433A discloses a "taxus plant extract and its application". The extract contains paclitaxel, and paclitaxel has relatively la...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B63/00C07D305/14C07D311/30C07D307/92C07C49/617A61K31/365A61K36/00A61P35/00
Inventor 王志国
Owner HARBIN HONGDOUSHAN TECH DEV
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