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A technology of intestinal trefoil factor and oral preparations, applied in pill delivery, medical preparations containing active ingredients, digestive system, etc., can solve problems such as interfering with glucose metabolism, promoting gluconeogenesis, and affecting cell functions
Inactive Publication Date: 2006-09-20
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology
But most of them are non-specific. In addition to promoting intestinal mucosal proliferation and repair, they also affect other cell functions. For example, growth hormone can interfere with glucose metabolism and promote gluconeogenesis, which limits its application in diabetic patients and severe trauma patients. Another example is fibroblast growth factor, insulin-like growth factor, etc., which have the side effects of promoting the expression of bacterial drug resistance genes and promoting the growth of tumor cells.
In conclusion, the current biopharmaceutical preparations prepared from the above-mentioned prodrugs have many defects in the treatment of gastrointestinal diseases
Method used
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Effect test
Embodiment 1
[0048]After mixing 5.3 kg of lactose, 6 g of glossoidin and 50 g of coloring agent, 0.48 kg of gum arabic is added to make a uniform soft material, which is granulated through a 16-mesh sieve. The wet granules are dried in an oven at 45°C, and the dry granules are sized through a 14-mesh sieve. Take another 50ml of 95% ethanol to mix with 10g of peppermint oil and spray evenly on the dry particles. Add 60g magnesium stearate evenly and place it in an open container for 1 hour, then add 0.1g of intestinal trefoil factor, 30g sucralfate and 10g glycine, 5g lysine, 15g vitamin C, 1gNa 3 PO 4 After mixing, add it and press 10,000 tablets, each containing 10μg of ITF.
Embodiment 2
[0050] The preparation process is the same as in Example 1, and the ingredients are as follows:
[0051] Intestinal trefoil factor (any one of the above ITF) 0.1g
[0052] Sucralfate 10g
[0053] Chitin 15g
[0054] Vitamin C 15g
[0055] Na 3 PO 4 1g
[0056] Lactose 5.4kg
[0057] Stevioside 10g
[0058] Citric acid 40g
[0059] Colorant 40g
[0060] Arabic gum 0.35kg
[0061] Peppermint oil 20g
[0062] Polyethylene glycol 12g
[0063] It is obtained by pressing 10,000 tablets, each containing 10μg of ITF.
Embodiment 3
[0065] The preparation process is the same as in Example 1, and the ingredients are as follows:
[0066] Intestinal trefoil factor (any one of the above ITF) 0.1g
[0067] Hydroxyprolyl cellulose 60g
[0068] Glycine 20g
[0069] Lysine 10g
[0070] Chitin 8g
[0071] Vitamin C 20g
[0072] Na 3 PO 4 0.5g
[0073] Sucrose 5.1g
[0074] Stevioside 10g
[0075] Citric acid 40g
[0076] Coloring agent 50g
[0077] Gelatin 0.6kg
[0078] Peppermint oil 10g
[0079] It is obtained by pressing 10,000 tablets, each containing 10μg of ITF.
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Abstract
The invention belongs to pharmaceutical preparations containing protein materials. It is an oral preparation of intestinal trefoil factor, which is characterized in that it contains intestinal trefoil factor as a pharmacodynamic active component, and also contains intestinal trefoil factor activator and intestinal trefoil factor protective agent. It is clinically used for the treatment of gastrointestinal ischemia-hypoxic injury, such as peptic ulcer, radiation enteritis, chronic gastritis, enteritis and other diseases caused by various reasons, and can rapidly promote the proliferation of gastrointestinal epithelial cells, Stabilizes the gastrointestinal mucus layer, does not interfere with glucose metabolism and promote gluconeogenesis, and has no side effects of promoting the expression of bacterial drug resistance genes and promoting the growth of tumor cells.
Description
1. Technical Field [0001] The invention belongs to a pharmaceutical preparation containing protein materials, and particularly relates to a biomedical preparation containing a specific growth factor-intestinal trefoil factor (ITF for short, the same hereinafter). 2. Background technology [0002] The gastrointestinal digestive tract is the corridor through which food and water lead to the body. It is often subject to mechanical and chemical (especially strong acid and alkali substances) impacts, and is often attacked by other harmful or toxic substances. More opportunities for loss. Modern medical research shows that the gastrointestinal tract is very sensitive to ischemic and hypoxic injury, and the gastrointestinal tract is one of the body's most vulnerable organs under various pathological conditions. Therefore, how to reduce gastrointestinal damage and promote damage repair is extremely important. Although the gastrointestinal protective drugs used clinically such as sucralfa...
Claims
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