Poly alpha-alcohol acid ester/chitosan ultrafine fiber hybridization film material and its preparation

A hydroxyester and microfiber technology, applied in medical science, prosthesis, etc., can solve problems such as no research reports or invention patents on hybrid microfiber membranes, and achieve adjustable degradation rate and tensile strength. Good, the effect of the preparation method is simple

Inactive Publication Date: 2006-12-27
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing microfiber repair membrane materials, there are no research reports or invention patents on hybrid microfiber membranes formed by co-electrospinning of natural and synthetic polymers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take M η 50,000 d, l-PLA 2.2g, dissolved in 10mL DMF at room temperature, and added 1% triethylbenzene ammonium chloride to make spinning solution. Take M η 0.6g of chitosan with a concentration of 200,000, and 0.6g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98%, were dissolved in 10mL of 2% dilute acetic acid at room temperature under magnetic stirring, and then the two were mixed Another 20 mL spinning solution was formed. Inject the above two spinning solutions into two 50mL syringes with inner diameter 0.8mm flat needles respectively, fix the syringes on the double-channel micro-syringe pump, and place a grounded metal receiving screen vertically at a distance of 10cm from the needles. Connect the needle to a 10kV high-voltage DC power supply, set the solution flow rate to 0.1mL / h for electrospinning, and collect ultrafine fiber hybrid films with a diameter of 100nm to 300nm on the receiving screen after 72 hours, in which chi...

Embodiment 2

[0013] Take M η 50,000 d,l-PLA 2.2g was dissolved in 10mL DMF at room temperature to prepare a spinning solution. Take M η 0.6g of chitosan for 650,000, and take M η 0.6 g of 2.3 million PEO was dissolved in 20 mL of 2% dilute acetic acid at room temperature under magnetic stirring to obtain another spinning solution. Using the same dual-channel electrospinning device, inject the above two spinning solutions into two 50mL syringes with a flat needle with an inner diameter of 0.8mm, respectively, when the receiving distance is 15cm, the voltage is 15kV, and the solution flow rate is 0.1mL / h Electrospinning is carried out under the conditions, and after 72 hours, a superfine fiber hybrid film with a diameter of 100nm-500nm is collected on the receiving screen, wherein the content of chitosan is 1%-20%.

Embodiment 3

[0015] Take M η 50,000 PLGA75 / 252.2g, dissolved in 10mL DMF at room temperature, and added 1% triethylbenzene ammonium chloride to make spinning solution. Take M η 0.6g of chitosan with a concentration of 200,000, and 0.6g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98%, were dissolved in 10mL of 2% dilute acetic acid at room temperature under magnetic stirring, and then the two were mixed Another 20 mL spinning solution was formed. Inject the above two spinning solutions into two 50mL syringes with inner diameter 0.8mm flat needles respectively, fix the syringes on the double-channel micro-syringe pump, and place a grounded metal receiving screen vertically at a distance of 10cm from the needles. Connect the needle to a 10kV high-voltage DC power supply, set the solution flow rate to 0.1mL / h for electrospinning, and collect ultrafine fiber hybrid films with a diameter of 100nm to 300nm on the receiving screen after 72 hours, in which chi...

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Abstract

A poly alpha alcohol acid ester / chitosan superfine fiber hybridization material and the preparation process thereof are disclosed. It belongs to tissue repairing material technology. The film having thickness of 10 mu m-50 mu m is formed by poly alpha alcohol acid ester fiber, the diameter of which being 50nm-500nm, chitosan, the mass percent of which is 10-90%, polyvinyl alcohol or polyoxyethylene, the diameter thereof being 50nm-500nm. The preparation process is as follows: dissolving PLA or PLGA into N,N- dimethytoluamide to prepare poly alpha alcohol acid ester spinning solution with concentration being 20%-25%, dissolving chitosan to acetic acid aqueous solution, adding polyvinyl alcohol or polyoxyethylene to solution to prepare for chitosan spinning solution with concentration 4%-8%, injecting said spinning solutions separately to the multi-channel electrostatic spinning device, conduct simultaneously electrostatic spinning and film converging in separate channels to prepare for film, with the voltage being 5kV-30kV, liquid inventory being 0.1mL / h-0.5mL / h, receiving range being 5cm-25cm. The film has advantages of large water absorption, regulatable degrading rate and favorable cellular affinity.

Description

technical field [0001] The invention relates to a polyalpha-hydroxy acid ester / chitosan superfine fiber hybrid membrane material and a preparation method thereof, belonging to tissue repair material technology. Background technique [0002] The raw materials of tissue repair materials include natural materials and synthetic biodegradable polymer materials. Compared with natural macromolecules, biodegradable aliphatic polyα-hydroxyesters such as polyglycolide (PGA), polylactide (PLA) and their copolymers (PLGA) have excellent mechanical properties but lack cell affinity and chitosan is a natural polysaccharide with good cell affinity. Using the method of electrospinning, ultrafine fibers with a diameter of 50nm to 500nm can be prepared from these polymers, and the ultrafine fiber non-woven membrane can be directly formed, which is equivalent to the scale of collagen and glycosaminoglycan in the extracellular matrix, suitable for For the reconstruction of tissues such as ski...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/60
Inventor 袁晓燕姚康德董存海段斌张园园
Owner TIANJIN UNIV
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