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Process for preparing extract containing hypericin and flavon compounds

A technology of flavonoids and hypericin, applied in the directions of organic chemistry, quinone separation/purification, etc., can solve the problems of difficult extraction, low solubility of hypericin, etc., and achieve the effects of increasing stability and simple process operation.

Inactive Publication Date: 2003-01-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention utilizes the solubilization effect of other components in Hypericum perforatum to extract hypericin from medicinal materials with an organic solvent, and solves the problem that hypericin is difficult to extract due to its low solubility in organic solvents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take Hypericum perforatum medicinal material powder 1100g, ethanol extraction 3 times, 6600ml each time, 1 day each time, combine the ethanol extracts and concentrate under reduced pressure to obtain 21g black solid with hypericin content 0.32%.

Embodiment 2

[0021] Take Hypericum perforatum medicinal material powder 1100g, extract 3 times with acetone, 6600ml each time, extract 3 times, 1 day each time, combine the acetone extracts and concentrate under reduced pressure to obtain 12g of black solid with a hypericin content of 0.6%.

Embodiment 3

[0023] Hypericum perforatum powder 400g, extracted 3 times with acetone, 2500ml each time, 1 day each time, combined the acetone extract and added 4000ml distilled water, then extracted 3 times with petroleum ether, 1200ml each time, combined the acetone water layer, at 60°C Concentrate under reduced pressure to 1500ml, adjust the pH of the resulting aqueous solution to 0 with hydrochloric acid, and let stand at 4°C for 72 hours. Centrifuge, and freeze-dry the precipitate to obtain 8.40 g of brown extract, the content of hypericin is 2.3%, and the content of total flavonoids (calculated as rutin) is 64.2%.

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PUM

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Abstract

The present invention relates to the preparation process of extract containing hypericin and flavone compounds. The technological process includes extraction with polar organic solvent, biphase extraction and acid precipitation and through the simple process the extract containing total effective component not less than 50%, hypericin of 2-4 % and general flavone up to 50-90 % may be obtained. Inthe technological process, composite stabilizer is used, so that the extracted product may be maintained stably.

Description

technical field [0001] The invention relates to a preparation method of an extract rich in hypericin and flavonoids. Background technique [0002] Hypericin (Hypericin) is one of the antidepressant active ingredients in Hypericum perforatum, which was first widely used in the field of antidepressant. In addition, antiviral in vitro and in vivo experiments show that hypericin can inhibit human immunodeficiency virus (HIV) and some other retroviruses. Such as: It has inhibitory effect on herpes simplex virus type 1, type 2 (HSV-1, HSV-2), parainfluenza virus, vaccinia virus, herpes stomatitis virus and human macrophage virus. Hypericin has a therapeutic effect on the infection of Friend leukemia virus in mice. The anti-tumor effect of hypericin has also attracted the close attention of scientists. Hypericin can directly cause apoptosis of cancer cells, accompanied by the release of cytochrome C from mitochondria to cytoplasm. [0003] Hyper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C46/10C07C50/36C07D311/30
Inventor 杨得坡黄世亮王发松谭英
Owner SUN YAT SEN UNIV
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