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Medicine for curing angiocardiopathy and its preparation method

A cardiovascular and worm technology, which is applied in the field of worm drugs for treating cardiovascular diseases and its preparation, can solve the problems of not using 5 kinds of worms at the same time to treat cardiovascular diseases and the effect of drug effects, and achieves improvement of blood rheology, Guaranteed drug efficacy and thrombolytic effect

Inactive Publication Date: 2003-04-23
北京中科天鹤生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The author has confirmed through literature search that there is no record or research practice of using 5 kinds of worms to treat cardiovascular diseases at the same time.
[0010] At the same time, it has been confirmed by literature search that most insect medicines are traditionally processed (such as the above-mentioned documents), which has affected the efficacy of the above insect medicines to a certain extent.

Method used

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  • Medicine for curing angiocardiopathy and its preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] After 2kg of cleaned scorpions, 0.5kg of centipedes, 1.5kg of earthworms, 1.5kg of ground beetles and 1.5kg of leeches were mixed in proportion, they were ground and homogenized with a colloid mill. Then collect the ground slurry and squeeze it with a filter press to separate the filter residue from the filtrate. The filtrate is dried by a vacuum freeze dryer to prepare a dry powder. After the filter residue is decalcified, protein removed, and bleached to extract chitin, it is then Digestion, drying and other processes are prepared into chitosan. After the dry powder and the chitosan are respectively pulverized, mixed, thoroughly mixed, and packaged, 2.16 kg of the medicine of the present invention are obtained.

Embodiment 2

[0040] After cleaning 15kg scorpion, 10kg centipede, 20kg earthworm, 20kg ground beetle and 25kg leech are mixed in proportion, grind and homogenate with colloid mill. Then the ground slurry is collected and squeezed by a filter press to separate the filter residue from the filtrate, and the filtrate is dried by a vacuum freeze dryer to prepare a dry powder, and chitin is extracted from the filter residue to prepare chitosan. After the dry powder and the chitosan are pulverized respectively, mixed, thoroughly mixed, and packaged, 28.96 kg of the medicine of the present invention are obtained.

Embodiment 3

[0042] Influence of the medicine of the present invention on the blood biochemical indexes of dogs with experimental myocardial ischemic infarction

[0043] Adopt ligation of coronary artery to cause canine acute myocardial ischemia model, then infuse the drug of the present invention through duodenum, intubate to coronary venous sinus through external jugular vein, measure the effect of different experimental time points before ligation of coronary artery medicine and after medicine. Serum creatine phosphokinase (CPK), serum lactate dehydrogenase (LDH) and plasma endothelin (ET). The experimental results show that, compared with the control group, the worm medicine can significantly inhibit the increase of CPK activity caused by myocardial ischemia and myocardial infarction (P<0.01), can reduce the content of ET (P<0.05), and has an inhibitory effect on LDH (P<0.05). It is confirmed that the worm medicine has inhibitory effect on experimental acute myocardial ischemia and ac...

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Abstract

The Chinese medicine made up by using (by weight portion) 15-25 portions of scorpion, 5-15 portions of centipede, 10-20 portions of earthworm, 15-25 portions of wingless cockroach and 15-25 portions of leech through the processes of cleaning, grinding, pressing, extracting, freeze-drying and mixing if possesses the functions of promoting blood circulation, freeing channels and quickening the network revessels and stopping pain and can be used for improving cardiovascular function and curing angiocardiopathy.

Description

technical field [0001] The invention belongs to the field of medicine and health care, and relates to an insect medicine for treating cardiovascular diseases and a preparation method thereof, in particular to an insect prepared from five kinds of fresh insects including scorpions, centipedes, earthworms, wood beetles and leeches Medicine and its preparation method. Background technique [0002] According to Xinhua News Agency, the World Heart Federation announced on September 1, 2001 that for every three deaths in the world, one of them died of cardiovascular disease. Death rates from cardiovascular disease remain far higher than from other diseases, including AIDS. The latest statistics released by it show that in 1999, about 17 million people died of cardiovascular diseases in the world, which accounted for nearly one-third of the world's deaths in that year. Therefore, it is necessary to strengthen the research on drugs for the treatment of cardiov...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K35/64A61K35/646A61K35/648A61P9/10
Inventor 张廷军韩晓琨
Owner 北京中科天鹤生物技术有限公司
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