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Prepn and application in preparing cancer-treating medicine of mistletoe alkaloid

The technology of mistletoe and anticancer drug is applied to the preparation method of mistletoe and its application field in the preparation of drugs for treating cancer, which can solve the problems of low curative effect and unsatisfactory curative effect of cancer, and achieve high cancer activity and low toxicity. , Anti-cancer broad-spectrum effect

Inactive Publication Date: 2003-05-14
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Chinese patent medicines on cancer is generally low. For example, Shenlian Capsules has a tumor remission rate of 3.5% for lung and stomach cancer, which is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Leafy stems of ginkgo mistletoe, crushed after natural air-drying. 5 kg of pulverized mistletoe coarse powder was extracted with 95% ethanol under 10-fold reflux for 5 hours, and the ethanol in the extract was recovered under reduced pressure and concentrated to extract. Add 1000ml of 2% hydrochloric acid, stir well to dissolve the alkaloids, let stand, pour out the supernatant, filter with suction, put the filtrate in a 1000ml separatory funnel, add concentrated ammonia water dropwise to adjust the pH to 9, and free the alkaloids. Add 300ml of chloroform, shake and extract, separate the chloroform layer, and extract the upper basic aqueous solution with chloroform for 8 times. Combine the chloroform solutions, wash with water, dry with anhydrous sodium sulfate, recover the chloroform, let it stand still, and precipitate crystals, namely mistletoe base.

Embodiment 2

[0029] Leafy stems of ginkgo mistletoe, crushed after natural air-drying. 2 kg of pulverized mistletoe coarse powder was extracted with 70% ethanol at 6 times of reflux for 3 hours, and the ethanol in the extract was recovered under reduced pressure and concentrated to extract. Add 700ml of 1% hydrochloric acid, stir well to dissolve the alkaloid, let stand, pour out the supernatant, filter with suction, put the filtrate in a 1000ml separatory funnel, add concentrated ammonia dropwise to adjust the pH to 9, and free the alkaloid. Add 150ml of chloroform, shake and extract, separate the chloroform layer, and extract the upper basic aqueous solution with chloroform four times. Combine the chloroform solutions, wash with water, dry with anhydrous sodium sulfate, recover the chloroform, let it stand still, and precipitate crystals, namely mistletoe base. .

Embodiment 3

[0031] Using the leafy stems of mistletoe as raw material, the extraction method and steps are the same as in Example 1.

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PUM

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Abstract

The present invention relates to an anticarcinogen prepared through extraction from mistletoe. The extraction process of mistletoe alkaloid includes the steps of: drying and crushing raw material, ethanol reflux extraction, reduced pressure recovering ethanol in extractive liquid, concentration to obtain extract, hydrochloric acid dissolution of alkaloid, still standing, extracting supernatant liquid, sucking filtering, adding dropwise concentrated ammonia water to free alkaloid, chloroform extraction, water washing chloroform liquid, drying with anhydrous sodium sulfate, recovering chloroform, and still standing to separate mistletoe alkaloid crystal. The medicine mistletoe alkaloid has obvious inhibiting effect on liver cancer, stomach cancer oesophagus cancer and mammary cancer, and has high anticancer activity, wide anticancer spectrum and less toxicity.

Description

1. Technical field: [0001] The invention relates to a preparation method and application of anticancer drugs, in particular to alkaloids extracted from Chinese herbal medicines as raw materials and their application in the preparation of drugs for treating cancer. 2. Background technology: [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cancer cases in my country every year, and about 1.3 million people die of cancer every year. The number of deaths from cancer in the country is increasing year by year. my country is a high-incidence area for liver cancer, gastric cancer, esophageal cancer, breast cancer, lung cancer and other cancers, and the mortality rate of cancer remains high. [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have a certain effect on cancer, they have serious side effects. The curative effect of Chinese patent medicines on cancer is gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P35/00C07D311/30C07G5/00C07H17/07
Inventor 章永红彭海燕
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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