The invention provides a Chinese traditional medicine compound prescription, and a preparation method and the purpose thereof, which mainly provides the Chinese traditional medicine compound prescription consisting of evodia, marsdenia tenacissima, climbing nightshade, oriental biter weed, Chinese fevervine, spatholobus stem, honey-suckle stem, wild grapevine, sargentg loryvine, Radix sophora flavescens, Paris Rhizome, licorice, etc. The preparation method comprisesthe following steps: step one, the alcohol reflux or the warm immersion abstraction of the evodia and the climbing nightshade, step two, the water extract-ethanol precipitation of gruffs and the rest medicinal materials, and step three, the blending of aqueous extract and ethanol extract. The invention provides the purposes of the compound prescription and the extract for the medicines of curing lung cancer, liver cancer, stomach cancer, rectal cancer, oophoroma, cervical carcinoma, prostatic cancer, bone cancer and other cancers, and simultaneously the invention also provides all administration forms including oral administration, rectum administration, intramuscular administration, vena administration, nasal cavity administration, vagina administration, subcutaneous administration, etc., and all preparation forms accepted by pellet, hard capsule, soft capsule, granula, oral liquid, syrup and pharmacy.