Methylamino-pterin derivative with inhibiting nitric oxide synthetase function
A technology of compounds and derivatives, applied in the field of new MTX derivatives, can solve the problems of high toxicity, narrow anti-cancer spectrum, and expanding anti-cancer spectrum.
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[0074] 1. Instruments and reagents:
[0075] The melting point of each compound in this experiment was determined by Mel-TEMP melting point apparatus, and the temperature was not corrected. MS was determined by HP1100LC / MSD mass spectrometer. Silica gel GF for thin layer chromatography (TLC) plates 254 (Qingdao Ocean Chemical Factory) and 0.8% CMC-Na distilled aqueous solution are stirred evenly and then paved, then activated at 100-110°C for 1h, placed in a desiccator for future use, and placed under an ultraviolet lamp (wavelength 254nm and 365nm) for color development; column chromatography adopts 100-200 or 200-300 mesh silica gel (produced by Qingdao Ocean Chemical Factory), and the column is packed by dry method. The H-NMR spectrum is measured with a Bruck AV-300 nuclear magnetic resonance instrument, without special instructions, the solvent used is D 6 -DMSO. Elemental analysis was determined with an Elementar Vario EL III instrument. Reagents are commercially ava...
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