Methylamino-pterin derivative with inhibiting nitric oxide synthetase function

A technology of compounds and derivatives, applied in the field of new MTX derivatives, can solve the problems of high toxicity, narrow anti-cancer spectrum, and expanding anti-cancer spectrum.
CN100390174CInactive Publication Date: 2008-05-28CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2008-05-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to methylaminopterin derivatives with 4-amino structure modified, which inhibit effect of nitrogen monoxide synthetase and growth of tumors. They have wide anti-cancer spectrum and little toxic side effect so as to be used in preparation of medicines for tumors, cancers, arthritis and intestinal diseases as well as chemicals for birth control.
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Description

technical field

[0001] The present invention relates to a new class of MTX derivatives, and specifically relates to a methotrexate derivative with the effect of inhibiting nitric oxide synthase, which can improve the anti-tumor and anti-articular effects of the clinical drug MTX (methotrexate) Inflammation, treatment of intestinal diseases, as the activity of family planning, etc. Background technique

[0002] (1) Biochemical and pharmacological effects of MTX and its application

[0003] Tetrahydrofolates (abbreviated as THF) derivatives are extremely important substrates for various enzymes of one-carbon metabolism in cells, that is, donors of formyl, hydroxymethyl or methyl in pyrimidine and purine biosynthesis , plays an important role in the processes of DNA and RNA synthesis, replication and repair. The synthesis of tetrahydrofolate in cells is completed by folic acid through the action of dihydrofolate reductase (Dihydrofolate reductase, DHFR). Folic acid and metho...

Claims

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