Solution agent of antiallergi medicine contg. levocetirizine
A levocetirizine, anti-allergic technology, applied in the field of anti-allergic pharmaceutical compositions, can solve the problems of molecular aggregation, difficult patient acceptance, poor taste of solution preparations, etc., and achieves the effect of comfortable and easy to accept taste
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[0016] Specific embodiments: Example 1 Levocetirizine hydrochloride oral solution
[0017] formula:
[0018] Levocetirizine hydrochloride 0.5g
[0019] Sorbitol 250g
[0020] Polyethylene glycol 400 150ml
[0021] Polyvinylpyrrolidone 25g
[0022] Poloxamer (model F68) 10g
[0023] Propionic acid 1ml
[0024] Sodium saccharin 0.1g
[0025] Strawberry flavor 1ml
[0026] Citric acid-sodium citrate
[0027] Add distilled water to 1000ml
[0028] Preparation: Weigh (or measure) the raw and auxiliary materials according to the formula, take an appropriate amount of distilled water, slightly heat and stir to dissolve, use citric acid-sodium citrate buffer (take 30g of citric acid, add 200ml of water, adjust the pH with sodium hydroxide 5.5±0.2, spare.) Adjust the pH to 4.5-6.5, add distilled water to dilute to full volume, filter with 0.45μm microporous membrane, fill, stopper, cap, and sterilize (ASM water bath sterilization, 115.5℃, 30min), you can. Example 2 Levocetirizine Hydrochlo...
Example Embodiment
[0028] Preparation: Weigh (or measure) the raw and auxiliary materials according to the formula, take an appropriate amount of distilled water, slightly heat and stir to dissolve, use citric acid-sodium citrate buffer (take 30g of citric acid, add 200ml of water, adjust the pH with sodium hydroxide 5.5±0.2, spare.) Adjust the pH to 4.5-6.5, add distilled water to dilute to full volume, filter with 0.45μm microporous membrane, fill, stopper, cap, and sterilize (ASM water bath sterilization, 115.5℃, 30min), you can. Example 2 Levocetirizine Hydrochloride Oral Solution
[0029] formula:
[0030] Levocetirizine hydrochloride lg
[0031] Propylene glycol 100ml
[0032] Sorbitol 250g
[0033] Polyethylene glycol 400 100ml
[0034] Polyvinylpyrrolidone 20g
[0035] Poloxamer 5g
[0036] Sorbic acid 2g
[0037] Sodium saccharin 0.1g
[0038] Strawberry flavor 1ml
[0039] Citric acid-sodium citrate
[0040] Add distilled water to 1000ml
[0041] Preparation: Weigh (or measure) the raw and...
Example Embodiment
[0041] Preparation: Weigh (or measure) the raw and auxiliary materials according to the formula, take an appropriate amount of distilled water, slightly heat and stir to dissolve, use citric acid-sodium citrate buffer (take 30g of citric acid, add 200ml of water, adjust the pH with sodium hydroxide 5.5±0.2, spare.) Adjust the pH to 4.5-6.5, add distilled water to dilute to full volume, filter with 0.45μm microporous membrane, fill, stopper, cap, and sterilize (ASM water bath sterilization, 115.5℃, 30min), you can. Example 3 Levocetirizine Hydrochloride Oral Solution
[0042] formula:
[0043] Levocetirizine hydrochloride 0.5g
[0044] Sorbitol 180g
[0045] Polyethylene glycol 400 10ml
[0046] Polyvinylpyrrolidone 100g
[0047] Poloxamer (model F68) 5g
[0048] Sorbic acid 2g
[0049] Sodium saccharin 0.2g
[0050] Apple flavor 1ml
[0051] Citric acid-sodium citrate
[0052] Add distilled water to 1000ml
[0053] Preparation: Weigh (or measure) the raw and auxiliary materials ac...
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