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Compound prepn. contg. ceftazidime and tazobactam for injection use

A technology of tazobactam sodium and ceftazidime, applied in the field of compound preparations, can solve problems such as serious drug resistance, and achieve the effects of increasing adverse reactions, major social and economic benefits, and enhancing clinical antibacterial effects

Inactive Publication Date: 2003-05-21
海南瑞生堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented formulation contains an injectable solution containing cefazim tazoferbacillin calcium salt (CFT) with improved bactericidal activity against both gram-positive and negative microorganisms in mice compared to other drugs currently available on market or under development.

Problems solved by technology

This patented technical problem addressed in the patents relates to finding effective treatments for multirestropic bacteremia without producing multiple types of beta lactic acid called taurochlorine.

Method used

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Examples

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Embodiment Construction

[0012] specific implementation plan

[0013] The content of the present invention is specifically described below in conjunction with the examples.

[0014] The compound preparation is composed of ceftazidime and tazobactam sodium in a ratio of 3:1 (weight ratio). First prepare tazobactam sodium, make mixed suspension by 150g of tazobactam and water for injection, add sodium bicarbonate solution to adjust the pH value to 6.3 ± 0.1 to obtain tazobactam sodium solution, decolorize and remove by active carbon for injection Bacteria filtration, freeze-drying to obtain lyophilized powder of tazobactam sodium, crushed to obtain tazobactam sodium powder; then mix 450 g of ceftazidime and tazobactam sodium evenly, and divide into 1000 bottles to obtain ceftazidime and tazobactam sodium The sodium bactam is composed of a compound preparation in a ratio of 3:1 (weight ratio).

[0015] The in vivo antibacterial test showed that the 3:1 ratio of ceftazidime and tazobactam sodium compoun...

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PUM

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Abstract

The present invention relates to an injection eftazidine and tazobatan sodium compound preparation, in which their weight ratio of 3:1. Said invented compound preparation possesses synergistic and accumulative antibacterial action for drug-resistant strain.

Description

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Claims

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Application Information

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Owner 海南瑞生堂制药有限公司
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