Mannosan peptide injection and its preparation and use method

A mannanpeptide and injection technology, which is applied in the field of mannanpeptide injection and mannanpeptide injection preparation, can solve the problems of medical accidents, prone to infusion reactions, secondary pollution and the like

Inactive Publication Date: 2003-07-16
HENAN HAOMAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the main drug content in the existing dosage forms of mannan peptides is relatively small, and the existing mannan peptides for injection are likely to cause secondary pollution when they are used clinically (when they are added to infusions), and infusion reactions are prone to occur, sometimes Mistakes can also occur and cause medical malpractice, so there is a need for a new dosage form of mannan peptide that can avoid secondary pollution in large doses

Method used

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  • Mannosan peptide injection and its preparation and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Mannan peptide injection with a specification of 100 ml was prepared, which contained 10 mg of mannan peptide and 0.9 g of sodium chloride.

[0057]The formula or prescription is:

[0058] Mannan peptide (according to dry product) 0.1g

[0059] Sodium chloride 9.0g

[0060] Add water for injection to 1000ml

[0061] Among them, mannan peptide is the main drug of this product, and sodium chloride is the isotonic regulator.

[0062] Process method:

[0063] Take the prescribed amount of sodium chloride for injection and an appropriate amount of water for injection to prepare a concentrated solution of about 20% sodium chloride, add an appropriate amount of activated carbon, stir evenly, heat to a boil of about 15 mm, filter, and the filtrate is set aside.

[0064] Take the prescribed amount of mannan peptide and add an appropriate amount of water for injection to dissolve, filter to obtain a filtrate.

[0065] Combine the above two solutions and add water...

Embodiment 2

[0076] Mannan peptide injection with a specification of 100 ml was prepared, which contained 10 mg of mannan peptide and 5 g of glucose.

[0077] The formula or prescription is:

[0078] Mannan peptide (according to dry product) 0.1g

[0079] Glucose 50g

[0080] Add water for injection to 1000ml

[0081] Among them, mannan peptide is the main drug of this product, and glucose is the isotonic regulator.

[0082] Process method:

[0083] Take the prescribed amount of glucose and an appropriate amount of water for injection to prepare a concentrated glucose solution of about 20%, add an appropriate amount of activated carbon, stir evenly, heat to a boil of about 15mm, filter, and the filtrate is set aside.

[0084] Take the prescribed amount of mannan peptide and add water for injection to the prescribed amount, filter to obtain the filtrate.

[0085] Combine the above two solutions and add water for injection to the prescribed amount, filter through a 0.22um mi...

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Abstract

A manna peptide injection for intravenous drip is prepared from manna peptide, isotonic substance and water through preparing an aqueous solution of manna peptide, mixing it with an aqueous solution of isotonic substance, loading in bottle, sealing and sterilizing. The application method of this injection is also disclosed.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a mannan peptide injection. The mannan peptide injection can be directly applied to intravenous infusion. The invention also relates to a preparation method and a use method of the mannan peptide injection. Background technique [0002] Mannan peptide is a polysaccharide extracted from α-hemolytic streptococcus. Its chemical structure is α-mannan peptide. Polyactin A). It is generally performed using α-hemolytic streptococci isolated from the mouth and throat of healthy individuals33 # The strain is obtained by submerged fermentation and ethanol extraction from the culture medium. Mannan peptide is a white or yellowish odorless and tasteless amorphous powder with an average molecular weight of 71700, mainly containing polysaccharides (about 85-90%), and the ratio of mannose to a small amount of glucose is about 16:1. And it contains about 4.5-6.2% of protein, and the mannan peptide ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P7/06A61P11/00A61P31/00A61P35/00A61P35/02A61P37/04
Inventor 陈长潭黄羿
Owner HENAN HAOMAI PHARMA
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