Coating liquid for improving anticoagulant performance of surface of biomedical device and coating method

An anticoagulant, biomedical material technology, applied in the field of coating liquid and coating method for improving the anticoagulation performance of the surface of the biomedical device, can solve the problems of inability to stably exist on the surface of the device and no anticoagulation effect, etc. Excellent anticoagulant properties, long-term stability, and easy availability of raw materials

Inactive Publication Date: 2003-10-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, heparin is a water-soluble substance. When it is simply coated directly on the surface of the material, the heparin will disappear rapidly under the use environment and cannot exist stably on the surface of the device, so it has no effective anticoagulant effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The coating solution can be directly applied to biomedical devices with complex body structures by means of spin coating, dip coating, spray coating, etc., and can be cured at 30-100°C, and the curing time is 1-20°C. For 48 hours, a heparin polymer coating was formed. It is also possible to add 1-20% acrylic ester copolymers containing both carboxyl and hydroxyl groups that can be cross-linked. Coating modification of biomedical devices with complex body structures by means of spin coating, dip coating, spray coating and other industrially feasible methods. And curing at 30-200 DEG C, the curing time is 1-48 hours, to form a cross-linked heparin polymer coating. Embodiment 1: Preparation of heparin-benzalkonium chloride complex

[0028] (1) Dissolve 1.7 g of benzalkonium chloride in 6 g of isopropanol, then dilute with 4 g of deionized water;

[0029] (2) Dissolve 1 g of sodium heparin in 10 g of deionized water;

[0030] (3) Mix the above two solutions and stir rap...

Embodiment 2

[0031] (4) Use a centrifuge to centrifuge the suspension to obtain a white complex, that is, a heparin-benzalkonium chloride complex; wash with deionized water, and freeze-dry the heparin-benzalkonium chloride complex to constant weight. Embodiment 2: Preparation of heparin-three (dodecylmethylammonium chloride) complexes

[0032] (1) Dissolve 3.4 g of tris(dodecylmethylammonium chloride) in 6 g of isopropanol, then dilute with 4 g of deionized water;

[0033] (2) 4 g of sodium heparin was dissolved in 10 g of deionized water;

[0034] (3) Mix the above two solutions and stir rapidly for 30 seconds to obtain a suspension of the white complex;

[0035] (4) Centrifuge the suspension with a centrifuge to obtain a white complex, namely the heparin-tris(dodecylmethylammonium chloride) complex;

[0036] (5) Wash with deionized water, freeze-dry the heparin-tris(dodecylmethylammonium chloride) complex to constant weight. Embodiment 3: Preparation of heparin-hexadecylpyridinium chl...

Embodiment 3

[0036] (5) Wash with deionized water, freeze-dry the heparin-tris(dodecylmethylammonium chloride) complex to constant weight. Embodiment 3: Preparation of heparin-hexadecylpyridinium chloride complex

[0037] (6) Dissolve 5.7 g of cetylpyridinium chloride in 6 g of isopropanol, then dilute with 4 g of deionized water;

[0038] (7) Dissolve 3 g of heparin sodium in 10 g of deionized water;

[0039] (8) Mix the above two solutions and stir rapidly for 30 seconds to obtain a suspension of the white complex;

[0040] (9) Centrifuge the suspension with a centrifuge to obtain a white complex, namely the heparin-tris(dodecylmethylammonium chloride) complex;

[0041] (5) Wash with deionized water, freeze-dry the heparin-tris(dodecylmethylammonium chloride) complex to constant weight.

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Abstract

The present invention is the coating liquid and coating process for improving the surface anticoagulant performance of biomedicine device. The coating liquid consists of heparin quaternary ammonium salt composite prepared through the reaction between heparin and quaternary ammonium salt 0.1-30 wt%, hydrophobic polymer cellulose ester, polyurethane, polylactate or rosin ester 0.01-20 wt% and solvent in the balance amount. The composite coating forming process includes the following steps: adding polyacrylate or similar polymer with carboxyl group and hydroxyl group capable of cross-linked in1-20 wt% into the coating liquid; coating biomedicine device with complicated structure; and curing at 30-100 deg.c to form the cross-linked heparin polymer coating. The coating has excellent anticoagulant performance and stability.

Description

technical field [0001] The invention relates to a coating solution and a coating method for improving the anticoagulant performance of the surface of a biomedical device. Background technique [0002] Medical devices in contact with blood, such as various artificial blood vessels, artificial hearts, interventional catheters, guide wires, stents, etc., have been widely used in modern medical treatment. These devices are usually made of metal, ceramic, or polymer materials, which do not have anticoagulant properties by themselves. When the blood comes into contact with it, a series of physiological reactions will occur, such as the adsorption and activation of platelets, the activation of complement, the activation of the exogenous coagulation system, etc., which will eventually lead to the formation of thrombus. Therefore, improving the blood compatibility of medical devices in contact with blood through surface modification is an important issue in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10
Inventor 计剑任科峰沈家骢范德增孙福玉
Owner ZHEJIANG UNIV
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