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Orally taken antioxidant and antilipemic medicine

A blood lipid-lowering and anti-oxidation technology, applied in the field of plant materials, can solve the problems of expensive imported drugs, unbearable for ordinary patients, occasional myopathy and rhabdomyolysis, etc.

Inactive Publication Date: 2003-11-05
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Among the above-mentioned drugs, statins and fibrates have better blood lipid-lowering effects, but they all have certain side effects. The main adverse reactions of statins are abnormal liver function and myopathy, and the most common adverse reactions of fibrates are gastrointestinal reactions. It can cause stones, so patients with gallstones or gallbladder disease are contraindicated. Although the combination of fibrates and statins is also very effective, but occasionally myopathy and rhabdomyolysis occur.
[0008] At present, there are no blood-lipid-lowering drugs on the market in my country, and the imported related drugs are expensive and unaffordable for ordinary patients. Therefore, the development of cheap blood-lipid-lowering drugs without side effects is an urgent problem to be solved

Method used

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  • Orally taken antioxidant and antilipemic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Taking the preparation of 1000 tablets of the product of the present invention as an example, the raw materials, auxiliary materials and their proportions are as follows:

[0025] Forsythin 30g

[0026] Starch 150g

[0027] Lactose 120g

[0028] The preparation process is carried out according to the conventional process of pharmacy tablets, each tablet weighs 0.3g and contains 30mg forsythin.

[0029] Usage and dosage: Orally, take one tablet each time, three times a day, reduce for children.

Embodiment 2

[0031] Taking the preparation of 1000 capsules of the product of the present invention as an example, the raw materials, auxiliary materials and their proportions are as follows:

[0032] Forsythin 30g

[0033] Corn starch 35g

[0034] Magnesium stearate 5g

[0035] The preparation process is carried out according to the conventional process of pharmacy capsules, and each capsule contains 30 mg of forsythin.

[0036] Usage and dosage: Orally, one capsule each time, three times a day, reduce for children.

Embodiment 3

[0038] Taking the preparation of 1000g of the product granules of the present invention as an example, the raw materials and auxiliary materials and their proportions are as follows:

[0039] Forsythin 10g

[0040] Cane sugar powder 650g

[0041] Dextrin 340g

[0042] The preparation process is carried out according to the conventional process of pharmaceutics granules, and 1 g contains 10 mg of forsythin.

[0043] Usage and dosage: Orally, 3g each time, three times a day, reduce for children.

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Abstract

The orally taken antioxidant and antilipemic medicines include solid orally taken preparation prepared with forsythin and solid excipient in the weight ratio of 0.01-4 through mixing and conventionaltechnological process, and liquid orally taken preparation prepared with forsythin and liquid excipient in the weight ratio of 0.003-0.01 through mixing and conventional technological process. Test shows that forsythin as the active component of the present invention has excellent effect of clearing away hydroxy radical and can inhibit the oxidizing damage in tissue and cell organ level. The medicine of the present invention has also functions of delaying senility and reducing blood fat, etc.

Description

Technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Oxygen free radicals play a very important role in the occurrence and development of many human diseases, such as aging, tumor occurrence, cardiovascular and cerebrovascular diseases, organ ischemia-reperfusion injury, senile dementia, Parkinson’s disease, Arteriosclerosis, cataracts, complications of diabetes, alcoholic liver injury, chronic hepatitis, emphysema, etc. With the deepening of theoretical research on the relationship between oxygen free radicals and diseases, the application value of antioxidants has been paid more and more attention, and relevant antioxidant drugs have also received increasing attention. Some antioxidants are even used as ingredients in health foods, such as Vitamin E family, carotene, unsaturat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/06A61P39/06
Inventor 李发荣王喆之杨建雄
Owner SHAANXI NORMAL UNIV
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