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Pen device for administration of parathyroid hormone

A parathyroid hormone, pen-type technology, applied in the direction of drug devices, infusion sets, other medical devices, etc., can solve problems such as syringe extraction

Inactive Publication Date: 2004-01-14
ELI LILLY & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is often difficult to draw the exact amount of fluid with conventional syringes

Method used

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  • Pen device for administration of parathyroid hormone
  • Pen device for administration of parathyroid hormone
  • Pen device for administration of parathyroid hormone

Examples

Experimental program
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Effect test

Embodiment Construction

[0026] Detailed description of the preferred embodiment

[0027] figure 1 The pen device of the present invention is shown in . The pen device 10 takes the shape of a standard writing pen and has a clip 15 attached to the cap 16 which allows the pen to be securely secured in a pocket or other carrying device. Such as figure 2 As shown in , the cap 16 protects the pen needle 23 and provides access to a reservoir or cartridge 22 . To achieve the single dose feature of the present invention, the injector body of the pen device is provided with a hard stop. Although the position of the hard stop in the pen is not critical, it must be positioned in such a way that the dose adjustment knob 11 cannot be rotated outwards so that the The location where the pen delivers more than a predetermined maximum single dose. In cases where PTH is prescribed for the treatment of osteoporosis, a single daily dose of 80 μL has been established to be effective. Preferably, the hard stop is lo...

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PUM

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Abstract

A pen delivery device and a procedure for administering parathyroid hormone is provided to allow for the priming and injection of a single predetermined dose. The method is a three-step method using visual indicators to set the priming and injectable dose deliveries. The device is made of a minimal number of parts, which include a housing, a dose knob, a generally cylindrical disengaging assembly located within the proximal end of the dose knob, and an externally threaded drive stem. The pen device further includes a mechanism that prevents the user from dialing up a dosage greater than that remaining in the cartridge.

Description

Background of the invention [0001] The present invention relates to a device and method for the administration of parathyroid hormone (PTH). PTH is an 84 amino acid product secreted by the parathyroid glands of mammals that controls serum calcium levels through its actions on various tissues, including bone. The N-terminal remaining 34 amino acids (PTH(1-34)) of bovine and human PTH are considered to be biologically equivalent to the full range of hormones. It has been shown that N-terminal fragments of PTH (e.g. including 1-31 and 1-38) or PTHrP (PTH-related peptides / proteins) or other PTH analogs of either or both can Activating the PTH / PTHrP receptor, the amino-terminal fragment has similar physiological effects on bone mass, although the extent of such effects is variable. [0002] Administration of PTH and PTH fragments can be performed by subcutaneous injection using a conventional syringe and vial system in which the liquid PTH solution is manually withdrawn from the ...

Claims

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Application Information

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IPC IPC(8): A61M5/24A61M5/31A61M5/315
CPCA61M2205/585A61M2205/582A61M5/31538A61M5/3146A61M2205/581A61M5/31541A61M2005/3125A61M5/3158A61M5/24A61M5/31551A61M2205/583A61M5/3155A61M5/315
Inventor M·J·雷
Owner ELI LILLY & CO
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