Plant extract for preventing and treating diabetes, and preparing method and pharmaceutic use thereof

A technology of plant extracts and diabetes, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems that have not been reported

Inactive Publication Date: 2004-04-14
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the research on chemical components with antid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation 1 of plant extract

[0021] Taxus coarse powder 60kg, reflux extraction with 4 times of volume 90% ethanol three times, the merging extract is concentrated into thick solution; 2 O two-phase extraction, combined the water layer, filtered, put on a macroporous resin column (D101 type, domestic), and eluted with distilled water and hydrous ethanol (ethanol: 5%-20%) gradient, and each eluent was tested with a differential test The eluents that showed a positive reaction were combined and concentrated to dryness in a rotary evaporator, recrystallized from ethanol, filtered to obtain a crystalline powder, dried, and dried at 70°C to obtain a plant extract (light yellow powder ), yield 0.10%. The HPLC method is used for detection, and the content of myo-inositol derivatives reaches 81%.

Embodiment 2

[0022] Embodiment 2: Preparation 2 of plant extract

[0023] Taxus coarse powder 70kg, extract three times at 50 ℃ with 3 times volume of 80% methanol, combine extracts, concentrate into slurry solution; Ethyl ester / H 2 O two-phase extraction, combined water layer, filtered, put on macroporous resin column (MN-200 type), gradient elution with distilled water and hydrous ethanol (ethanol: 5%-20%), and each eluent was used for identification test The eluents that showed a positive reaction were combined, concentrated to dryness under reduced pressure in a rotary evaporator, recrystallized from acetone, filtered to obtain a crystalline powder, dried, and dried at 70°C to obtain a plant extract (off-white powder ). Yield 0.12%. The HPLC method is used for detection, and the content of myo-inositol derivatives reaches 75%.

Embodiment 3

[0024] Embodiment 3: Preparation 3 of plant extract

[0025] Taxus coarse powder 65kg, extracted three times with 4 times the volume of 75% acetone at 45 ° C, the combined extracts were concentrated into a thick solution; concentrated to dryness under reduced pressure with a rotary evaporator, and dichloromethane / H 2 O Two-phase extraction, combined water layer, filtered, put on activated carbon (pharmaceutical specification) column, gradient elution with distilled water and hydrous ethanol (ethanol: 5%-30%), each eluent was identified with differential test solution , combined the eluents showing a positive reaction, concentrated to dryness under reduced pressure in a rotary evaporator, recrystallized from methanol, filtered to obtain a crystalline powder, dried, and dried at 70°C to obtain a plant extract (light yellow powder) , yield 0.13%. The HPLC method is used for detection, and the content of myo-inositol derivatives reaches 66%.

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PUM

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Abstract

The invention refers to a plant extract to prevent and cure diabetes, extracted from Taxus spp, especially Taxusyunnanensis Cheng et L.K.Fu, Taxus chinensis var.mairei(Lemee et Levl)Cheng et L.K.Fu, etc. It refers to making method and usage. The content of main component of the plant extract powder, myo-inosite derivant compound, can reach above 60%.

Description

field of invention [0001] The present invention relates to a plant extract for preventing and treating diabetes extracted from Taxus spp, especially Taxusyunnanensis Cheng et L.K.Fu, Taxus chinensis var.mairei (Lemee et Levl) Cheng et L.K.Fu, etc. substances, their preparation methods and their medicinal uses. Background technique [0002] With the acceleration of the aging process of the world population, diabetes has become a common and frequently-occurring disease. At present, the pathogenesis of diabetes is still not very clear, and its treatment mainly uses drugs to reduce hyperglycemia and prevent complications. The invention and application of insulin and main oral hypoglycemic chemical synthetic drugs have brought hope to diabetic patients, but they still have serious drug side effects such as hypoglycemia and lactic acidosis, which affect their use and efficacy (Wang Zhongxiao, Shanxi Medical University Acta Sinica, 2000 31(6):555-556). Finding and developing hig...

Claims

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Application Information

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IPC IPC(8): A61K31/337A61P3/10
Inventor 梁敬钰吴斐华鲍官虎程奇蕾
Owner CHINA PHARM UNIV
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