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Application of high-solubility berberine in preparation of medicine.

A high-solubility, berberine-based technology, applied in the direction of antibacterial drugs, anti-tumor drugs, drug combinations, etc., can solve obstacles to research and development in the field of technology, high prices, and do not consider the possibility of animal drugs to treat human diseases, etc. question

Inactive Publication Date: 2004-05-12
吴开敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Slow effect and long course of treatment—according to literature records, after taking Avandia for 26 weeks, the fasting blood sugar decreased by an average of 2.1-2.8mmoI / L; in my country, a study was conducted on 442 patients with type 2 diabetes after taking Avandia for 24 weeks The results showed that fasting blood sugar decreased by an average of 1.5mmoI / L
[0009] 3. The price is expensive - up to 17.09 yuan per piece
[0020] The phenomenon in Article 5 that seems very unfair today and the technical prejudice formed by humans not being able to take veterinary drugs have continued for decades, causing people not to consider the possibility of using animal drugs to treat human diseases, which has long hindered People's research and development in this field of technology

Method used

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  • Application of high-solubility berberine in preparation of medicine.
  • Application of high-solubility berberine in preparation of medicine.
  • Application of high-solubility berberine in preparation of medicine.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Animal experiment

[0033] A1 (berberine hydrogen sulfate) and A2 (berberine sulfate) anti-hyperglycemia test report

[0034] 1. Experimental purpose: To observe the hypoglycemic effect of A1 and A2 on hyperglycemic animals through animal experiments.

[0035] 2. Drugs to be tested: A1 and A2 are both yellow powders, which are dissolved in warm boiled water to the required concentration before the test and administered to animals (i.g.).

[0036] 3. Experimental animals: km mice were purchased from the Department of Experimental Animal Science, Fudan University, Shanghai, clean grade, license scxk Shanghai No. 2002-002.

[0037] 4. Main reagents: streptozotocin (streptozotocin) is a Sigma product, analytically pure, and made into a 1.5% solution with 0.05 mol / L citric acid.

[0038] 5. Test method:

[0039] Km mice fasted for 24 hours, male, weighing 18.0-22.5 g, were injected with 150 mg / kg streptozotocin into the tail vein, and blood was collected from the retroocu...

Embodiment 2

[0054] Clinical Trials

[0055] A total of 35 patients diagnosed with type 2 diabetes mellitus were selected, including 20 males and 15 females; 25 first-timers and 10 re-treatment patients; 6 cases with fasting blood glucose 13.9mmol / L5 cases. All patients had symptoms of polydipsia, polyphagia, polyuria, and hunger in varying degrees. On the basis of strict diet control, berberine with high solubility is used alone for treatment, and berberine sulfate and the like are made into capsules, each 0.3g. According to the severity of each person's condition, the duration of the disease, and the fasting blood sugar level before meals in recent days, each person takes 1 to 4 capsules each time (gradually increase from the minimum dose), 3 times a day. Individuals with the original dawn phenomenon (elevated blood sugar from 4 to 8 in the morning) can be taken once more at 2 in the morning. The course of treatment is generally 1 to 3 months. Except for 2 cases of poor curative effec...

Embodiment 3

[0057] The drug made by combining high-soluble berberine (preferably berberine sulfate) and houttuyonin has synergistic antibacterial and antiviral effects without antagonism and can greatly reduce their drug resistance to the body. Infectious diseases can obtain better curative effect.

[0058] The formula for preparing the combined preparation is preferably in the range of weight percent: 50-80% of berberine sulfate, and 20-50% of houttuyonin.

[0059] The optimal percentage by weight of the formula for preparing its joint preparation is: berberine sulfate 20%. Houttuyniatin 30%.

[0060] The above two medicines are mixed according to the amount and prepared into oral preparations (preferably capsules or tablets). Adults take 0.3-1.2g orally each time (gradually increase from the minimum dose), three times a day, once after each meal, and for those with serious conditions, take an additional dose before going to bed at night.

[0061] The houttuyonin in the above formula ...

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Abstract

The present invention relates to the application of high-solubility berberine in the preparation of medicine for curing and preventing diabetes and its complicating diseases. The described berberine includes other berberine except for berberine hydrochloride, high-solubility berberine which can be dissolved in the water and animal berberine. They are easily dissolved in water, can make the medicine be easily absorbed by human body so as to greatly raise therapeutic effect. The medicine also can be used for curing and preventing tumor or cancer and other various infective diseases.

Description

technical field [0001] The invention relates to a new application of berberine (except berberine hydrochloride), in particular to the application of high-solubility berberine in the preparation of drugs for treating or preventing diabetes and its complications, tumors and cancers, and human antibacterial drugs. Background technique [0002] With the continuous improvement of people's living standards and the continuous extension of the average life expectancy of human beings, physical health has been regarded as the primary symbol of happiness in life, but the number of patients with some common diseases, frequently-occurring diseases, and difficult diseases is increasing. Listed by the World Health Organization (WHO) and the International Diabetes Federation (IDF) as the third major disease that endangers human health - diabetes is spreading rapidly around the world. There are more than 150 million people with diabetes in the world, and our country has reached 40 million, a...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/14A61K9/20A61K9/48A61K31/4375A61P3/10A61P31/12A61P31/14A61P35/00
Inventor 吴开敏
Owner 吴开敏
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