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Method for preparing qingkailing granules

A technology of granules and honeysuckle, applied in the direction of anti-inflammatory agents, antiviral agents, pharmaceutical formulations, etc., can solve the problems of unacceptable by patients, troublesome embedding process, complicated preparation process, etc., achieve good emulsification stability, reduce loss, good taste effect

Inactive Publication Date: 2004-07-21
增城市广增药物研究所
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AI Technical Summary

Problems solved by technology

[0003] As the main active ingredients in Qingkailing Granules, some medicinal materials, such as baicalin, taurocholic acid, hyodeoxycholic acid, etc., are extremely bitter medicines, and some animal ointments are difficult to drink. In short, The product of Qingkailing prepared according to the preparation process of conventional Chinese patent medicine granules has a bad taste and is unacceptable to patients
The patent of CN1288724 and CN1247078 discloses a kind of preparation method of Qingkailing granule, but what adopted in CN1288724 is that cholic acid and animal paste are embedded with cyclodextrin, and its embedding process is cumbersome, and the embedding rate Low, the extracts of Chinese medicinal materials honeysuckle, isatidis, and gardenia are spray-dried, so the overall preparation process is complicated, the production cost is high, and the mouthfeel of the medicine is still adjusted by using auxiliary material sugar powder; CN1288724 patent also has mouthfeel The problem, too, is the use of a lot of powdered sugar
Such products cannot be used by diabetics. For this reason, it is necessary for us to solve the taste problem from the preparation method

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0011] The preparation method of Qingkailing Granules:

[0012] (1) Weigh 13 g of raw materials taurocholic acid, 15 g of hyodeoxycholic acid, 200 g of mother-of-pearl powder, 100 g of buffalo horn powder, 20 g of baicalin, 100 g of gardenia, 800 g of Radix Radix, and 20 g of honeysuckle extract for use.

[0013] (2) Preparation of mother-of-pearl powder and buffalo horn powder hydrolyzate: get buffalo horn powder and use 8 times the amount of 4mol / l barium hydroxide to heat and hydrolyze it for 6 to 7 hours and then take the filtrate for subsequent use; get mother-of-pearl powder and use 8 times the amount of 4mol / l sulfuric acid solution is heated and hydrolyzed for 6-7 hours, let cool and take the filtrate, add it to the hydrolyzate of buffalo horn, adjust the pH to 4 with barium hydroxide, concentrate the filtrate and precipitate it with ethanol, take the filtrate to recover ethanol, and adjust the pH to 7 Finally, the filtrate is concentrated into an extract for later us...

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Abstract

A medicine 'Qingkailing particles' for treating diabetes is prepared through adding the aqueous extract of honeysuckle flower, capejasmine fruit and isatis root, the hydrolyzed liquid of buffalo horn powder and nacre powder, ox-chololic acid, hyodeoxycholic acid, and baicalin to the aqueous solution of starch at 60-90 deg.C, stirring, emulsifying spray drying, mixing with additive and granulating.

Description

technical field [0001] The invention relates to a method for preparing granules with Chinese medicinal materials as main raw materials. Background technique [0002] Qingkailing Granules is a Chinese patent medicine with Chinese herbal medicines as the main raw materials. This product has the functions of clearing away heat and detoxification, calming the nerves, and mainly treating colds and fevers. This product has been listed as an essential drug by the Chinese Ministry of Health. When there is a specific drug for the treatment of atypical pneumonia, as a clinical application of the Chinese patent medicine Qingkailing preparation, the relevant Chinese administrative agency has released Qingkailing preparation as a drug with certain curative effect in the treatment of SARS. [0003] As the main active ingredients in Qingkailing Granules, some medicinal materials, such as baicalin, taurocholic acid, hyodeoxycholic acid, etc., are extremely bitter medicines, and some animal...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K35/32A61K35/618A61P11/00A61P25/20A61P29/00A61P31/00A61P31/14
Inventor 欧瑞华周炳琪李卫梅
Owner 增城市广增药物研究所
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