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Application of Chinese medicine polysaccharide as colonic drug-transferring carrier

A colon and drug delivery technology, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients to achieve obvious therapeutic effects, convenient administration, and significant targeting.

Inactive Publication Date: 2004-07-28
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is known that rhubarb polysaccharide has obvious hypolipidemic and anticoagulant effects, but this effect has not been applied in the pharmaceutical field

Method used

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Examples

Experimental program
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Embodiment Construction

[0011] The present invention relates to the application of traditional Chinese medicine polysaccharide as a colon-targeted drug delivery carrier to achieve colon-localized drug delivery. The following will take rhubarb polysaccharide as a colon-targeted drug delivery carrier as an example to describe the technical solution of the present invention in detail, but the present invention is not limited to the examples range described.

[0012] The prodrugs for the treatment of ulcerative colitis involved in the present invention include 5-aminosalicylic acid prodrugs, that is, the linker between rhubarb polysaccharide and 5-aminosalicylic acid; glucocorticoid prodrugs, that is, glucocorticoids and Subdivided types such as linkers of rhubarb polysaccharides.

[0013] The preparation method of the polysaccharide-dexamethasone prodrug and its pharmacological test and results on TNBS-induced colitis in rats will be described below to illustrate its use in the field of pharmacy.

[00...

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Abstract

The present invention relates to an application of Chinese medicine polysaccharide in pharmaceutical field, in the concrete, it relates to an application of Chinese medicine polysaccharide as medicine-transferring carrier for colon. The Chinese medicine polysaccharide has clear biological activity, in particular, the rhubarb polysaccharide self-body has obvious biological activity, in which the rhubarb polysaccharide component whose molecular weight range is in (5-3)X10 to the power 5 has obvious colonic medicine-transferring target effect, so that it can obtain obvious therapeutic action for curing colitis. According to the requirements it can be made into various dosage forms.

Description

Technical field: [0001] The invention relates to the application of traditional Chinese medicine polysaccharides in the field of pharmacy, in particular to the application of traditional Chinese medicine polysaccharides as a colon-targeted drug delivery carrier. Background technique: [0002] Rhubarb polysaccharide is isolated and purified from the traditional Chinese medicine rhubarb. The extraction method is as follows: crush rhubarb, remove fat-soluble components with ethanol, and then separate and purify by hot water extraction, ethanol precipitation, gel chromatography or ultrafiltration separation to obtain the rhubarb polysaccharide fraction. During the extraction process, the purity analysis was carried out by polyacrylamide gel electrophoresis, qualitative identification by ultraviolet and infrared spectroscopy, the sulfuric acid-phenol method and sulfuric acid-carbazole method were used to determine the sugar content and uronic acid content respectively, chromatogr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P1/00
Inventor 梅其炳周四元刘莉
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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