Chinese medicine gelsmium elegans total alkaloid for anticancer and analgesia, and medicinal composition containing it and preparing method thereof

The technology of total alkaloid and composition is applied in the field of anti-cancer and pain-relieving traditional Chinese medicine Goukou total alkaloid and pharmaceutical composition containing the same and the preparation field thereof, and can solve the problems of easy to reach toxic dose, low sensitivity, extensive and the like

Inactive Publication Date: 2004-09-15
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have also shown that kinesin alkaloids only have a general cytotoxic effect on proliferating cells and have no selectivity, and they also have effects on normal cells, but the sensitivity is lower than that of tumor cells
[0005] 2 Effects on the immune system
Although its "production cost is low, and the production process is simple", its mechanism of action is unknown, and its effect has not been reported, and the pain and inconvenience caused by long-term (one course of treatment is 3 months) application of this type of plaster are unbearable
From the perspective of the composition, there are too many highly toxic and highly toxic drugs among the 20 traditional Chinese medicines, especially Nuxynum and Glycyrrhizae, whose alkaloids are similar, and the effective dose is relatively close to the toxic dose, and the toxic dose is easy to reach after combined use , it is uncertain whether it will bring toxic side effects to patients
[0016] Based on the above-mentioned domestic patent applications for hook kiss application, it is still in a relatively extensive stage, and there is a considerable gap with domestic and foreign research on hook kiss

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Crush the medicinal material Gelkins into a coarse powder, add 8-10 times the amount (based on the weight of the raw material) of ethanol for extraction, filter to obtain the filtrate, repeat the extraction of the filter residue 1-2 times, and combine the extracts; concentrate under reduced pressure, recover ethanol, to The relative density is 1.10-1.15 to obtain a concentrated solution; an equivalent amount of water is added to the concentrated solution to adjust the pH of the solution to be 2.0-3.0 to obtain a total alkaloid salt solution of Gelcyonium alkaloids; an equivalent amount of ( (in solution volume) chloroform, adjust the pH of the mixed solution to 10.0 with 40% alkali solution, vibrate vigorously for 15-20min, let stand for 20-30min, and separate the chloroform phase; repeat the chloroform extraction step 1-2 times, and combine the chloroform phase; The remaining liquid was extracted twice with an equal amount of ethyl acetate, and the extracts were combine...

Embodiment 2

[0073] Pulverize the Gypsy medicinal material, add an acidic (PH2. The second filtrate was added with 40% lye, the pH was adjusted to 10, and the alkaloid was allowed to stand overnight. Filtration to obtain gynecine alkaloid precipitation. Suspend the precipitate in 10 times the amount of acidic aqueous solution (pH 2.0), dissolve it, and obtain the total alkaloid solution of kelp. Add an equal amount (volume ratio) of chloroform to the solution, and adjust the pH of the mixed solution to 9-10, oscillate, stand still, separate the chloroform phase, repeat the chloroform extraction once, and combine the chloroform solution twice; the water phase is extracted with an equal amount of ethyl acetate 2 times, combined ethyl acetate solution. Under reduced pressure, recover chloroform and ethyl acetate respectively to 1 / 4 of the original volume to obtain the total alkaloid extract of citronella; dissolve the two extracts with acidic aqueous solution to obtain the total alkaloid aq...

Embodiment 3

[0076]Pulverize the medicinal material Gelkins, add 1-1.5 times the amount of raw materials in lye (PH=10) to moisten, airtightly dry after 24 hours, add 6-8 times the amount of raw materials in chloroform and soak for 12 hours, percolate, and add chloroform to the filter residue Chloroform volume meter) continue to soak for 8h, press filter, combine two filtrates, recover chloroform under reduced pressure to 1 / 2 of the original volume; add an equivalent amount of water to the concentrated chloroform solution, adjust the pH of the mixed solution to 2.0 with 40% hydrochloric acid solution , fully oscillated for 15 minutes and left to stand for 30 minutes to separate the water phase; repeat the water extraction step once, combine the water extracts, carefully adjust the pH of the aqueous solution to 6.0-7.0, and add a non-polar adsorption resin of 1 / 8 (parts by weight) of the original medicinal material , slowly stirred and adsorbed overnight at room temperature, filtered to obta...

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Abstract

The invention discloses an anticancer and antalgic Chinese medicinal Gelsmium elegans total alkaloid and drug combination containing it as well as its preparing method, where the Gelsmium elegans total alkaloid is extracted from the raw material Chinese medicinal Gelsmium elegans and the Gelsmium elegans total alkaloid and acceptable carrier or excipient in any pharmacy are made into drug combination whose drug form can be oral preparation and also injection, concretely speaking tablet, capsule, soft capsule, oral solution, injection solution, transfusion, powder injection and freeze-dried powder injection. The drug combination has good anticancer effect and high-quality ntalgic function and the drug combination's antalgic strength is inferior to morphia's and superior to other clinical antalgics'.

Description

Technical field [0001] The present invention relates to a kind of total alkaloids of the traditional Chinese medicine Gelzilis used for anticancer and analgesia, a pharmaceutical composition containing the same and a preparation method thereof. technical background: [0002] Gelkins is the whole herb of Struggleaceae plant vine, which is a world-renowned highly poisonous plant. Warm in nature, pungent and bitter in taste, highly toxic. The research on hook kisses at home and abroad is very extensive. Since the 1930s when Chinese scholars began to isolate kelsin, alkaloids such as kelsin A, B, C, D, E, Zi, Chou, Yin, Mao, and Chen have been isolated; the 1970s have begun The total synthesis of kelezin was obtained, and the pharmacological effects and clinical applications of several kelezins were studied. Its pharmacological effects are manifested in the following aspects: [0003] 1 Antitumor effect [0004] It was observed in experiments that Geekkising Injection has a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P25/04A61P29/00A61P35/00C07G5/00
Inventor 张晴龙
Owner 张晴龙
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