Modified technique for making zedoary turmeric oil and glucose injection

A technology of zedoary oil and injection, which is applied in the field of preparation of zedoary oil and glucose injection, and can solve the problems of 5-hydroxymethylfurfural such as large changes, poor stability, and difficult preservation

Inactive Publication Date: 2004-11-17
LI MIN PHARM FAB OF LIVZON PHARM GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Zedoary Oil Injection obtained by this conventional method has poor stability and is not easy to preserve, and the 5-hydroxymethylfurfural in it changes greatly

Method used

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  • Modified technique for making zedoary turmeric oil and glucose injection
  • Modified technique for making zedoary turmeric oil and glucose injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Get curcuma oil equivalent to 1.6g of curcumol (taking the content of curcumol as 100% feed intake) and add 17.6g of Tween-80 to warm and fully emulsify to obtain a mixed solution;

[0014] Take 180g of anhydrous glucose to make a 60% solution, add 0.5ml of 1% hydrochloric acid and 2g of activated carbon, stir, boil for 30 minutes, take out, cool to 50-60°C, filter to remove charcoal to obtain a mixed solution;

[0015] Combine the above-mentioned emulsified mixed solution and the decarbonized mixed solution, add water to nearly 4000ml, and divide into two equal parts.

[0016] Adjust the pH value of a part of the mixture obtained above to 4.0-4.5 with 5% NACL or HCL, add water to 2000ml, coarse filter, and then pass through a 0.45μm and 0.22um filter membrane for fine filtration, and then fill it in In a 100ml infusion bottle, ventilate with nitrogen, press the cap, and sterilize at 105° C. for 30 minutes to obtain the injection A in injection lot number 1.

[0017] A...

Embodiment 2-5

[0019] According to the production process of Example 1, according to the difference between the zedoary oil used in Table 1 and the Tween used, two solutions of A and B with batch numbers of 2-5 were produced respectively.

Embodiment 6

[0021] In this embodiment, the changes of various stability indexes of the two samples of A and B were compared.

[0022] Simultaneously measure the content and pH value of samples A and B before and after sterilization, and calculate the percentage decrease of 5-hydroxymethylfurfural content after sterilization. Part of the remaining part is accelerated in a 37-40°C incubator, and the other part is stored in a sample storage room. , 1 month, 2 months, 3 months, 6 months, 12 months and 18 months simultaneously measure A, B room temperature storage and the sample of accelerated test (1 month, 2 months, 3 months) Content, pH value, 5-hydroxymethylfurfural, calculate the percentage of content decrease. (Using the same reference substance and the same reagent at the same time, and operating at the same time can eliminate the errors caused by the reference substance, reagents and operators, and increase the comparability of A and B samples.)

[0023] 1. Changes before and after ...

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PUM

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Abstract

The invention relates to an improved process for preparing aromatic turmeric oil glucose injection which comprises, charging right amount of tween into aromatic turmeric oil, emulsifying sufficiently, preparing glucose solution, charging in right amount of activated charcoal, agitating, boiling a finite period of time, filtering, combining the two liquids, charing water for injection and sodium citrate or citric acid, dissolving with EDTA-2Na, adjusting pH to 3.5-5.0, and producing high capacity injection.

Description

technical field [0001] The invention relates to an improved method for preparing zedoary oil glucose injection. Background technique [0002] Curcuma oil is an ingredient extracted from the traditional Chinese medicine Curcuma zedoary. It contains more than 20 chemical components, which have the functions of promoting qi, promoting blood circulation and removing blood stasis, clearing heat, eliminating accumulation and relieving pain, removing putrefaction and promoting muscle growth. Through modern pharmacological research, it is found that zedoary oil has the following effects: 1) broad-spectrum anti-pathogenic microorganisms and anti-inflammation; Cancer effect: directly inhibit and destroy cancer cells, but have no effect on normal tissues. It can prevent the occurrence of cervical cancer, inhibit abnormal tissue hyperplasia, and promote the atrophy of hyperplastic tissue. [0003] Existing zedoary oil has multiple formulations, such as suppositories, capsules, freeze-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/26A61P29/00A61P31/00A61P35/00A61P37/04A61P43/00
Inventor 谢伟宏叶建山刘学华陈茂如
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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