Rosa banksiae general lactone extract and its preparing process and application

A technology for total lactones and extracts, which is applied in the field of preparation of the total lactones of woodsy, can solve the problems of low yield of woody volatile oil and the like, and achieves the effects of improved content and stability, good process repeatability and low operating temperature

Inactive Publication Date: 2005-01-26
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that the yield of extracting the volatile oil of Akira sinensis by steam distillation is low, and the extraction rate of the volatile oil of Akira sinensis can be improved by using carbon dioxide supercritical technology, but this meth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0079] Example 1:

[0080] Take 100 kg of woody medicinal materials, pulverize into coarse powder, add 4 times the amount of 100% ethanol and reflux for extraction 2 times, each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to remove ethanol, add 100L of water and mix well, then add 100L separately Petroleum ether was extracted twice, the petroleum ether layer was separated, and concentrated under reduced pressure at 60°C under 0.09MP conditions to obtain 3.3 kg of total costal lactones with a content of 69.6%.

Example Embodiment

[0081] Example 2:

[0082] Take 100 kg of woody medicinal materials, crush them into coarse powder, add 4 times the amount of 90% ethanol and reflux for extraction twice, each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to remove ethanol, add 100L of water to mix, and then add them separately 100L of ethyl acetate was extracted twice, the ethyl acetate layer was separated, and concentrated under reduced pressure at 70°C under 0.09MP conditions to obtain 3.1 kg of total costus lactones with a content of 56.3%.

Example Embodiment

[0083] Example 3:

[0084] Take 100kg of woody medicinal materials, pulverize into coarse powder, add 4 times the amount of 10% ethanol and reflux for extraction 2 times, each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to remove ethanol, add 100L of water and mix well, then add 100L separately Petroleum ether was extracted twice, and the petroleum ether layer was separated, and concentrated under reduced pressure at 75° C. under 0.09MP conditions to obtain 3.2 kg of total costus lactones with a content of 71.3%.

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Abstract

The invention discloses a sosa banksiae general lactone extract and its preparing process and use in preparing pharmaceutical composition using the costuslactone as active composition for treating cholecystitis and gallstone diseases, the preparation process comprises, comminuting the banksia rose, extracting by adding right amount of alcohol solvent, condensing, charging water, esters, hydrocarbons or ethers organic solvent for extraction, separating the organic solvent layer, and removing the organic solvent through decompression and concentration.

Description

technical field [0001] The present invention relates to a preparation method of total lactones extracted and separated from the traditional Chinese medicine chrysanthemum and used for treating cholecystitis and gallstone, as well as an extract and a pharmaceutical composition prepared by the method. Background technique [0002] Cholecystitis is clinical common disease, frequently-occurring disease. In my country, with the continuous improvement of people's living standards and changes in eating habits, the incidence of cholecystitis and gallstones is on the rise, and the incidence in some large cities is close to the level of developed countries. [0003] Western medicine mainly treats cholecystitis or gallstones by anti-inflammation, expansion of the gallbladder and biliary sphincter. For severe patients, surgery is used to solve the problem. However, the side effects of Western medicine are large, and it is difficult for patients to tolerate it for a long time. And clin...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/16C07D307/93
Inventor 王强俞祥生黄芸杨永安张喜全
Owner CHINA PHARM UNIV
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