High-efficient liquid-phase chromatographic testing method for copper in aspirin

A technology of high performance liquid chromatography and determination method, which is applied in the field of determination of aspirin copper by high performance liquid chromatography, can solve the problems of aspirin copper decomposition, complex sample components, and increase the difficulty of separation, so as to achieve high solubility, shorten dissolution time, simplify The effect of the compounding process
CN1584588AInactive Publication Date: 2005-02-23KUNMING INST OF PRECIOUS METALS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KUNMING INST OF PRECIOUS METALS
Publication Date
2005-02-23
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

A coppr acetylsalicylate high efficient liquid chromatography using liquid phase chromatograph with ultraviolet detector and chromatographic column of octadecylsilane linkage silica gel is featured as using liquid of methanol: water: THF: glacial acetic acid=45:52.5:2.5:0.5 as liquid phase and using 276 mm as detecting wavelength.
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Description

technical field

[0001] The invention relates to a high-performance liquid chromatography determination method for aspirin copper. Background technique

[0002] Chromatographic analysis is often used in drug separation and quantitative analysis research because of its fast, sensitive, and high-resolution characteristics. It is one of the important methods for drug purity analysis and an indispensable method for purity testing required by the Pharmacopoeia.

[0003] Copper Aspirin [Cu(ASA) 2 ] 2 It is a new type of aspirin derivative, which has higher anti-inflammatory and anti-thrombotic effects than aspirin, and has less toxic and side effects. Research and development are carried out in the center, and the clinical research work has been basically completed. Matching its research and development, [Cu(ASA) 2 ] 2 The current purity analysis method and impurity determination method is high performance liquid chromatography internal standard method. When using this method...

Claims

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