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Microfluid analytical system using magnetic microsphere as medium and ivestigating method thereof

A technology of magnetic microspheres and analysis systems, which is applied in the fields of material analysis, material excitation analysis, color/spectral characteristic measurement, etc. It can solve the problems of unreasonable structure of the background technology and inability to meet high-throughput detection, and achieve sufficient reaction and cleaning. Effect

Active Publication Date: 2005-03-23
XIAN GOLDMAG NANOBIOTECH
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Problems solved by technology

[0007] The invention solves the technical problem that the structure of the background technology is unreasonable, it can only be used for qualitative detection, and cannot satisfy high-throughput detection

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  • Microfluid analytical system using magnetic microsphere as medium and ivestigating method thereof
  • Microfluid analytical system using magnetic microsphere as medium and ivestigating method thereof
  • Microfluid analytical system using magnetic microsphere as medium and ivestigating method thereof

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specific Embodiment approach

[0035] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention aims at different reactions, such as antigen-antibody reactions, nucleic acid hybridization reactions, receptor-ligand reactions, etc., immobilizing a biologically active molecule on the surface of magnetic microspheres or magnetic fluorescent microspheres. The entire reaction and cleaning process is completed in the chip, and the single-flux or multi-flux detection of bioactive molecules is further realized by designing an optical detection system above the microfluidic chip.

[0036] see figure 2 , the microfluidic analysis system of the present invention is made up of microfluidic device 6, reaction carrier 4, controllable external magnetic field 7 and optical analysis system 8 and data analysis system 9, and reaction carrier 4 can adopt magnetic polymer microsphere or magnetic polymer Fluorescent microspheres.

[0037] image 3 , 4 A schematic diagram showing the structure of the microfluidi...

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Abstract

The invention discloses a micro fluid analysis system which is leaded by magnetic microsphere, the system includes micro fluid analysis system equipment, optic analysis system and data analysis system which is set in the output end of the optic analysis system, reaction carrier is in the micro fluid equipment, the optics analysis system includes detector, reaction aisle and detector aisle joint where has valve; the reaction carrier is magnetic microsphere or magnetic fluorescent microsphere. The invention can control the course to process truly, using the magnetism of magnetic microsphere during reaction and cleanout; because the process can be controlled, the reaction carrier can select different radius magnetic microsphere or magnetic fluorescent microsphere. The detector can be set at different position according to the demand, and it can analyze the result by CCD shooting method, color testing by spectroscope, the invention can also test the result of magnetic fluorescent microsphere and fluorescence signal of the tiny surface by laser lamp-house system.

Description

technical field [0001] The invention relates to a microfluid analysis system mediated by magnetic microspheres and a detection method thereof. Background technique [0002] In 2000, a research group led by Kitamori of the University of Tokyo published a microfluidic chip detection device based on microspheres. This method used polymer polystyrene microspheres as biological reaction carriers, and labeled gold nanoparticles on the secondary antibody. As a detection signal, using a microfluidic reaction and detection device processed with barriers in the microfluidic channel, the nano gold particles marked on the surface of the microspheres are observed through a thermodynamic microscope above the microspheres near the barriers. Its detection system is attached figure 1 . Kitamori uses this system for immunological detection of tumor markers. The method is accurate and sensitive. Compared with the currently commonly used ELISA, the reaction time can be shortened from tens of ...

Claims

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Application Information

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IPC IPC(8): G01N21/25G01N21/64G01N33/53G01N33/533G01N33/543G01N33/551
Inventor 崔亚丽陈超
Owner XIAN GOLDMAG NANOBIOTECH
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