Methods and compositions for control of coccidiosis
A composition and coccidial technology, applied in the prevention or amelioration of animal coccidial infection, reduction or improvement of animal coccidial infection, prevention field, can solve problems such as negative impact on productivity, subclinical infection and the like
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Embodiment 1
[0022] A 28-day experiment was conducted with 360 Cornish Rock male broiler chicks to study the inhibitory effects of two drug-containing feeds on the deleterious effects of E. tenella (see Tables I & II).
[0023] Day-old chicks were fed a standard diet containing monensin (60 g / kg) or a yeast cell wall / mannooligosaccharide composition (BIO-MOS®, Alltech, Inc., Nicholasville, KY) (1 kg / ton). Corn soybean feed. The test groups included: 1) negative control group (no drug treatment, non-challenge); 2) positive control group (no drug treatment, challenge); 3) monensin treatment, challenge group and 4) BIO-MOS®-treatment, attack group. Within each treatment group, chicks were randomly assigned to three identical pens. At 14 days of age, chicks were infected by gavage with E. tenella (50,000 oocysts / chick). Response variables measured included weekly body weight gain and cecal lesion scores as described (Johnson and Reid. 1970 "Anticoccidial Drugs: Lesion Scoring Technique in B...
Embodiment 2
[0026] A 28-day experiment was conducted with 360 Cornish Rock male broiler chicks to study the inhibitory effect of two medicated diets on E. maxima infection. Thirty one-day-old chicks per treatment group were housed in side-by-side cages and fed a standard soy-corn diet containing monensin (60 g / kg) or containing yeast cell wall material and mannooligosaccharides A commercially available composition derived from yeast cells (BIO-MOS®) (1 kg / ton). The four test groups included: 1) negative control group (no drug treatment, non-challenge); 2) positive control group (no drug treatment, challenge); 3) monensin treatment, challenge group, and 4) BIO-MOS® - Healing, attack groups. Chicks were assigned to treatment groups and to the same pens as described in Example 1.
[0027] At 14 days of age, chicks were infected by gavage with E. maxima (50,000 oocysts / chick). Response variables measured included weekly body weight gain and cecal lesion score. Such assays were subjected t...
Embodiment 3
[0031] A 28-day experiment was conducted with 360 Cornish Rock male broiler chicks to study the inhibitory effect of two drug-containing diets on E.acervulina infection.
[0032] Day-old chicks were fed a standard corn-soy diet containing salinomycin (6 mg / kg) or BIO-MOS(R) (1 kg / ton). The four experimental groups were: 1) negative control, no drug treatment, non-challenge group; 2) salinomycin treatment, challenge group; 3) BIO-MOS® treatment, challenge group, and 4) BIO-MOS® treatment, unchallenged group. Within each treatment group, chicks were randomly assigned to three identical pens. At 14 days of age, chicks were infected by gavage with E. acervulina (500,000 oocysts / chick). Response variables measured included weekly body weight gain and cecal lesion score. Data were subjected to ANOVA analysis as described in Example 1 using conventional linear model methods (SAS Institute, Cary, NC).
[0033] Like salinomycin, BIO-MOS(R) significantly attenuated cecal damage as i...
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