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Medicine for treating hepatitis and its preparing method

A drug and hepatitis technology, which is applied in the field of injection and its preparation, can solve the problems of poor technological advancement, loss of active ingredients, and influence on drug efficacy, etc.

Inactive Publication Date: 2005-08-03
曹春林 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Secondly, the advanced nature of the technology has been inferior
At that time, there was no national standard for the development of traditional Chinese medicine injections. Although Qingkailing Injection had carried out drug selection, screening and classification on the original prescription of "Angong Niuhuang Pills", and adopted separate extraction methods according to the different physical and chemical properties of the active ingredients, However, most of the processes used are boiling alcohol precipitation, alcohol reflux, stone sulfur method, etc., and the single flavor still needs repeated alcohol precipitation treatment to avoid precipitation. The loss of active ingredients directly affects the efficacy of the medicine

Method used

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  • Medicine for treating hepatitis and its preparing method
  • Medicine for treating hepatitis and its preparing method
  • Medicine for treating hepatitis and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Weigh the raw materials according to the following ratio:

[0167] Pig gall powder 30g Goat horn 50g Scutellaria baicalensis 60g

[0168] Honeysuckle 50g Gardenia 50g Banlangen 20g

[0169] Take pig bile powder, add 5 times the amount of 95% ethanol to reflux for 1.5 hours, let it cool, filter, wash the precipitate with a small amount of 95% ethanol, filter, combine the filtered washings, recover the ethanol until it has no alcohol smell, and dilute the concentrated solution with water to the medicinal material 2 ~3 times the amount, slowly add 2mol / L hydrochloric acid under stirring to adjust the pH value to 2.0-3.0, precipitate out, take it out, wash with water until neutral, dry under reduced pressure at 60°C to obtain crude cholic acid. Add 6 times the amount of crude cholic acid to 95% ethanol to dissolve, then add activated carbon with 10% of the amount of crude cholic acid, heat and reflux for 1 hour to decolorize, let cool, filter, add 40% NaOH to the filtrate ...

Embodiment 2

[0183] The extract of the six-flavor medicinal material was extracted by the same method as described in Example 1, and the extract of the six-flavor medicinal material was dissolved in an appropriate amount of water, and then 2% of the flavoring agent steviol glycoside was added, and it was used as the injection 2 -4 times the concentration to prepare oral liquid.

Embodiment 3

[0185] Use the same method as described in Example 1 to extract the extract of the six medicinal materials, fully dry the extract of the six medicinal materials, pulverize, and mix to obtain a mixture, add a small amount of water for injection to make it moist, and put it in a freeze-drying box Made into freeze-dried powder, aseptically subpackaged to obtain freeze-dried powder injection.

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Abstract

The present invention relates to a kind of medicine for treating hepatitis and its preparation process, and is especially a kind of injection and its preparation process. The medicine is compounded with the extract of six kinds of Chinese medicinal materials, including pig bile powder, goat horn, skullcap root, cape jasmine, honeysuckle and isatis root. The injection is compounded via adding injection water to the medicine, and medicine may be also prepared into other preparation forms. The medicine may be used in treating acute icterohepatitis, viral hepatitis, chronic hepatitis B, hepatitis C, hepatocirrhosis, and other liver diseases. The medicine has obvious curative effect.

Description

technical field [0001] The invention relates to a medicine for treating hepatitis and a preparation method thereof, in particular to an injection in the medicine and a preparation method thereof. Background technique [0002] my country is a high-incidence area of ​​viral hepatitis, with types A, B, and C as the main types, and type E also presents a regional incidence trend. Various types of hepatitis viruses have no immunity to each other, and they can develop independently or overlap with each other. Because of their similar clinical manifestations and pathological changes, they are also classified as viral hepatitis. Among them, hepatitis B is a worldwide infectious disease. About 280 million people in the world carry hepatitis B surface antigen (HBsAg), and Asia accounts for 220 million people. my country is a high-endemic area, about 40-60% of the population has been infected with hepatitis B virus (HBV), and the positive rate of HbsAg is about 10%, that is, about 120...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K35/32A61K35/413A61P1/16A61P31/12
Inventor 曹春林徐丽丽
Owner 曹春林
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