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Method for extended storage of blood and blood components

A technology for blood components and blood products, which is applied in the fields of medical preparations containing active ingredients, pharmaceutical formulations, preservation of human or animal bodies, etc. Problems such as preservation of whole blood and/or blood components to achieve the effect of prolonging the shelf life and reducing the content

Inactive Publication Date: 2005-08-10
SAFETIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each method has a number of disadvantages, including the fact that they are usually only suitable for one blood component and that the cleaning methods used can damage the blood component
In addition, the preservation method itself may damage blood components
Therefore, there is currently no suitable method for preserving whole blood and / or blood components that does not involve introducing potentially harmful chemicals into the body, nor does it involve damaging the whole blood and / or blood components themselves

Method used

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  • Method for extended storage of blood and blood components
  • Method for extended storage of blood and blood components
  • Method for extended storage of blood and blood components

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Embodiment Construction

[0035] The present invention provides a relatively nontoxic and reversible method of manipulating platelets and, optionally, other blood components. As noted above, the method of the present invention involves treatment with carbon monoxide in such a small amount that its toxicity is low enough to be tolerated by the body.

[0036] The present invention also provides a method of inhibiting the growth of bacteria in blood components by treatment with carbon monoxide, so that such methods can be used to prolong the storage life of these blood components. As detailed below, the present invention is preferably used to preserve platelets, which are particularly susceptible to infection by bacteria and other microorganisms, so the methods of the present invention are particularly applicable to platelets.

[0037] According to a preferred embodiment of the present invention, the whole blood provided by the donor is first separated into various components, and then, more preferably, o...

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Abstract

A method for inhibiting bacterial growth in whole blood and / or blood components, which may therefore also be used to extend the storage time for the whole blood and / or blood components, through treatment with carbon monoxide. This method is preferably used for the preservation of platelets, which are both particularly vulnerable to bacterial and other microbial infection, and which are also particularly suitable for use with the method of the present invention. Carbon monoxide may be present in an amount of from about 40% to about 100%. Platelets may be stored in a solution buffered by any suitable buffer, such as sodium bicarbonate. Platelet viability may be determined by measuring the ability to aggregate, for example in response to an agonist such as collagen.

Description

technical field [0001] The present invention relates to methods for long-term storage and preservation of blood and blood components by treating blood and / or blood components with CO (carbon monoxide). Background technique [0002] Blood transfusion is an important therapeutic adjunct in modern medicine. It is the mainstay of treatment in the field of emergency medicine. So blood has been collected and stored in blood banks since the beginning of the twentieth century. Originally collected and stored as whole blood, blood collected from donors is now separated into specific components before being stored and ultimately used to treat patients. Store these blood components in airtight plastic bags at temperatures ranging from -80°C to +24°C, depending on the component. Table 1 lists the current storage conditions for blood components. [0003] components storage period temperature(℃) Whole blood 24 hours 20～24 red blood cells ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00A61K35/14A61K41/00
CPCA61K41/0009A01N1/0215A61K35/14A61K41/10A01N1/00
Inventor 纽瑞斯·沙克拉
Owner SAFETIN