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Ligustrazine microcapsule and preparation method

A technology of ligustrazine and ligustrazine alkali salt, which is applied in the field of medicine, can solve the problems of unhelpful experimental research, non-biodegradable excipients, and different uses, and achieve the effect of sufficient raw materials in the market, prevention and treatment of intestinal adhesions, and prevention of intestinal adhesions

Inactive Publication Date: 2005-08-31
凌立君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method uses different techniques for combining these two technologies together with other ingredients such as barriers or slow-release systems. These methods produce particles smaller than usual but they still maintain their effectiveness over time due to its ability to gradually dissolve them into water without causing harmful substances like bacteria. It also includes certain types of herbs called liguthazene which help keep this solution stable during storage at room temperature. Overall, this new approach provides an effective way to control excessive buildup on tissues caused after surgery while reducing patient discomforts associated therewith.

Problems solved by technology

This patented technical problem addressed by these inventors relates to improving the way surgeries stop bleeding after gastrointestinal wall defects without causing painful symptoms during recovery periods due to blood clot formation. Current methods involve invasively removing tissue plugs called fibers through sutures, while other approaches like absorbent pumps have limitations including difficulty controlling their delivery rates over time, potential harm caused by foreign bodies implanted within patients' body vessels.

Method used

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Embodiment 1

[0024] The present embodiment prepares ligustrazine hydrochloride 20%, chitosan 15%, paraffin 40%, as emulsifier Span-80 2.5%, Tween-80 10%, the distilled water of above component total weight 12.5% ​​by weight percentage , prepare ligustrazine microcapsules according to the following method:

[0025] (1) under room temperature conditions, ligustrazine hydrochloride is dissolved in distilled water;

[0026] (2) Add liquid paraffin, and add Span-80, stir to form a water-in-oil emulsion (W / O);

[0027] (3) Add chitosan solution again, and add Tween-80 and stir to form a water-in-oil-in-water multiple emulsion (W / O / W);

[0028] (4) Use the complex emulsion as the injection liquid, the liquid surface distance is 2.5-3cm, the injection speed is 80mm / h (10ml / h, controlled at 5-15ml / h), the stirring speed is 150r / min, and the electrostatic field voltage is 2.2KV respectively Apply between the sharp hole and the solidification solution through two electrodes, add 4mol / L sodium hydro...

Embodiment 2

[0042] The present embodiment prepares ligustrazine phosphate 5%, chitosan 7.5%, paraffin 62.5%, as emulsifier Span-80 5%, Tween-80 10%, total weight 10% distilled water by weight percentage, according to the following Method for preparing ligustrazine microcapsules:

[0043] (1) at room temperature, ligustrazine phosphate is dissolved in distilled water;

[0044] (2) Add liquid paraffin, and add Span-80, stir to form a water-in-oil emulsion (W / O);

[0045] (3) Add chitosan solution and stir with Tween-80 to form water-in-oil-in-water multiple emulsion (W / O / W)

[0046](4) The complex emulsion is used as the injection liquid, the liquid surface distance is 2.5-3cm, the injection speed is 80mm / h (10ml / h, controlled at 5-15ml / h), the stirring speed is 150r / min, and the electrostatic field voltage is 2.2KV, Add 5mol / L potassium hydroxide solidified solution into the injection to form ligustrazine phosphate microcapsules with a particle size of 300um-800um and a multi-vesicle str...

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Abstract

A ligustraznie microsoftgel for preventing the adhesive intestinal infarction after operation is prepared from alkaline salt of ligustrazine, chitosan, paraffine wax and emulsifier proportionally through high-voltage electrostatic method.

Description

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Claims

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Application Information

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Owner 凌立君
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