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Extract of star of bethlehem and its prepn process, medicinal composition and use

A technology of tiger's eye and evergreen, applied in the field of tiger's eye evergreen extract, to achieve the effect of good anti-inflammatory effect, strong effect and broad economic value

Inactive Publication Date: 2005-09-28
吕新波 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report about the treatment of cholecystitis and cholecystitis-related diseases with the extract of Dieffenbachia tiger eye

Method used

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  • Extract of star of bethlehem and its prepn process, medicinal composition and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Extract Dieffenbachia tiger eye with extract method

[0045] (1) The medicine of the present invention was refluxed for 2 hours with 80% ethanol of 8 times the amount of crude drug (moisture 14%, the same below), and filtered;

[0046] (2) Medicinal residues plus 30% ethanol with 8 times the amount of crude drug were refluxed for 2 hours and filtered;

[0047] (3) Merge twice filtrate, after decompression reclaims ethanol for subsequent use;

[0048] (4) decoct the dregs with 8 times the amount of crude drug in water for 2 hours, and filter;

[0049] (5) The dregs were added to 7 times the crude drug amount and decocted in water for 1 hour, filtered, and the dregs were discarded.

[0050] (6) Combine the twice water-extracted filtrate and the medicinal solution after recovering ethanol, concentrate under reduced pressure to a relative density of about 1.10 (80°C), and fine-filter the concentrated solution.

[0051] The extract thus obtained contains:

[...

Embodiment 2

[0057] Embodiment 2: Single-component separation and extraction method extracts Dieffenbachia tiger eye

[0058] (1) Weak alkaloid extraction: Take 60.0 g of this product with dry constant weight, weigh it, powder it into 60 mesh, reflux with 85% ethanol for 2 hours (200ml×3), filter, combine the filtrates, and recover the ethanol to dryness. Dissolve in 50ml of water, extract with ether (30ml×2), discard the ether layer, extract the water layer with chloroform (30ml×5), recover the chloroform to dryness, and obtain about 230mg of weak alkaloid extract.

[0059] (2) Strong alkaloid extraction: Take 60.0g of this product with dry constant weight, weigh it, powder it into 60 mesh, reflux with 0.5% hydrochloric acid-ethanol for 2 hours (300ml×2), filter, combine the filtrates, recycle the ethanol to dryness , dissolved in 100ml of water and extracted with chloroform (50ml×3). After adjusting the pH of the aqueous layer to 11, it was extracted with chloroform (50ml×5), and the ch...

Embodiment 3

[0068] Embodiment 3: the preparation method of the capsule containing Dieffenbachia tiger eye extract

[0069] Ingredients: Dieffenbachia tiger eye 334g, Hedyotis diffusa 150g, Scutellaria barbata 150g, Salvia miltiorrhiza 75g, Polygonum cuspidatum 67g, Curcuma curcuma 75g, Panax ginseng 75g, Astragalus 150g, Scorpion scorpion 30g, Giant centipede 30g.

[0070] Preparation method: take Dieffenbachia tiger eye, use the method of Example 1 to obtain the extract, and spray-dry or freeze-dry to make fine powder for later use; East Asian scorpion and giant centipede three flavors are crushed into fine powder for later use; , put in the volatile oil extractor to extract the volatile oil, collect the volatile oil in another device for later use; after extracting the volatile oil, add 8, 8, and 6 times the amount of water to decoct the curcuma curcuma and Hedyotis diffusa and other six flavors for 3 times, followed by 3, 2, and 1 hour. Filtrate, combine the filtrates for three times, ...

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Abstract

The present invention is extract of star of Bethlehem, its preparation process, medicine composition with effective amount of the extract and their application in treating acute and chronic cholecystitis and relevant diseases. The medicine composition has the advantages of high curative effect, less toxicity, etc. and the present invention provides one new way of treating cholecystitis and relevant diseases.

Description

technical field [0001] The present invention relates to a tiger eye evergreen extract, a preparation method thereof, a pharmaceutical composition containing the extract, and the use of the extract and the pharmaceutical composition containing the extract, especially in the treatment of cholecystitis and cholecystitis Use in related diseases. Background technique [0002] Tiger eye evergreen (Omithogalum Caudatum Ait.) is native to southern Africa and is an ornamental plant of Liliaceae ("Chinese Seed Plant Family and Genera Dictionary"). There are potted plants in northern my country, which are mainly produced in Changbai Korean Autonomous County, Jilin Province. [0003] In 1992, Japanese scientist Sashida isolated from Ornithogalum saundersiae a Saunders saunders saponin compound with strong anticancer effect—Ornithogalum saundersiae saponin OSW-1. Its toxicity to a variety of cancer cells is more than 100 times higher than that of existing clinical drugs, but it has lit...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/20A61K9/48A61P1/16
Inventor 吕新波韩忠旭
Owner 吕新波
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