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Fat milk infusion with biological activity and production thereof

A biologically active and fat emulsion technology, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of undiscovered fat emulsion research reports and patent applications, and achieve stable and reliable products.

Inactive Publication Date: 2005-12-28
云南一尧科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, no fat emulsion research reports and patent applications of ent-kaurane diterpenoids have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Oridonin B fat emulsion infusion, formula:

[0027] Oridonin 18g

[0028] soybean oil 750g

[0029] Glycerin 125g

[0030] Soy Lecithin 75g

[0031] Preparation process: under the condition of grade 100, first dissolve Rubescensin B in an appropriate amount of soybean oil, and pay attention to make it completely dissolved; under the protection of nitrogen, add soybean lecithin to 2000ml of water for injection, and then add Rubescensin B Su soybean oil, soybean oil, glycerin, add water for injection to 5000ml; use tissue crushing mechanism at 70-80°C to obtain rough milk, quickly cool the rough milk to below 20°C, and then use a two-step high-pressure milk homogenizer Emulsify to obtain finely dispersed submicron emulsion (fat emulsion); filter with No. 4 vertical melting funnel, and send the fine filtrate to the filling machine, pack in 50ml per bottle, tie caps, pack, inspect, and pass the finished product. 100 bottles of finished product of oridonin fat emulsion i...

Embodiment 2

[0033] Fatty Emulsion Infusion of Camellia saponin B, formula:

[0034] Camellia saponin 10g

[0035] Safflower oil 6000g

[0036] Glycerin 1000g

[0037] Soy Lecithin 700g

[0038] Sub-preparation process: under the condition of 100 grades, dissolving calyxanthin in an appropriate amount of mixed oil of glycerin and safflower oil, and paying attention to make it completely dissolved. Under the protection of nitrogen, add soybean lecithin to 20000ml of water for injection, then add calyxanthin mixture, safflower oil and glycerin, and add water for injection to 50000ml. At 70-80°C, use a tissue crushing mechanism to obtain rough milk. The coarse milk is rapidly cooled to below 20°C, and then emulsified with a two-step high-pressure homogenizer to obtain a finely dispersed submicron emulsion (fat emulsion). Filter with a No. 4 vertical melting funnel, and the fine filtrate is sent to a packaging machine, divided into 50ml bottles, capped, packaged, inspected, and qualified....

Embodiment 3

[0040] Oridonin A succinate fat emulsion infusion, formula:

[0041] Oridonin A Succinate 40g

[0042] Perilla oil 6500g

[0043] Evening Primrose Oil 1000g

[0044] Glycerin 1200g

[0045] Soy Lecithin 700g

[0046]Preparation process: under the condition of grade 100, first dissolve oridonin A succinate in an appropriate amount of evening primrose oil and glycerin (1:1) mixed oil, and pay attention to make it completely dissolved. Under the protection of nitrogen, add soybean lecithin to 20000ml of water for injection, then add mixed oil of oridonin succinate, evening primrose oil, perilla oil, glycerin, and add water for injection to 50000ml. At 70-80°C, use a tissue crushing mechanism to obtain rough milk. The coarse milk is rapidly cooled to below 20°C, and then emulsified with a two-step high-pressure homogenizer to obtain a finely dispersed submicron emulsion (fat emulsion). Filter with a No. 4 vertical melting funnel, and the fine filtrate is sent to a packaging ...

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Abstract

A bioactive intralipid perfusion is proportionally prepared from p-kaurane diterpenoid and the medical assistant able to provide high-energy fatty acid or its derivative. Its advantages are high biologic utilization rate and stability and no irritation.

Description

technical field [0001] The present invention relates to a biologically active pharmaceutical preparation with antibacterial and antitumor effects, more precisely, it relates to an enantio-kaurane type 2 with better bioavailability, higher activity and better stability. Terpene compound fat emulsion infusion and its preparation method. Background technique [0002] Plants of the genus Isodon belong to the family Lamiaceae (Labiatae=Lamiaceae) and the subfamily Ocimoideae are perennial herbs, shrubs, and subshrubs. There are more than 150 species of plants in this genus, 90 species and 21 varieties in China, which are distributed all over the country, and more distributed in Yunnan. Camellia plants are rich in secondary metabolites of ent-kaurenoids. More than 80 of them have been studied and more than 500 diterpenoids have been found, most of which The ingredients have antibacterial activity, antitumor activity, antiviral activity, anti-oxidation, anti-mutation, anti-terato...

Claims

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Application Information

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IPC IPC(8): A61K31/352
Inventor 任杨帆
Owner 云南一尧科技开发有限公司
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