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Compound in category of trioside methyl salicylate, oside ester saccharide

A compound and drug technology, applied in the field of preparing the compound to achieve the effects of less irritation and stable properties

Inactive Publication Date: 2006-02-01
丁怡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no prior art on the use of such compounds

Method used

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  • Compound in category of trioside methyl salicylate, oside ester saccharide
  • Compound in category of trioside methyl salicylate, oside ester saccharide
  • Compound in category of trioside methyl salicylate, oside ester saccharide

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0035] For the first time, salicylate glycosides were extracted and isolated from Baizhu yunnanensis.

[0036] 9 kilograms of branches and leaves of Baizhu yunnanensis were extracted 3 times with 95% ethanol under reflux, then filtered, the filtrate was concentrated to a small volume, filtered again, and the filtrate was mixed with 1 kilogram of macroporous adsorption resin (Lukang 860021 type resin). After drying, add it to 1 kg of the same macroporous resin column that has been treated, and first wash it with water until the Molish reaction is negative, and then change it to 35 liters of ethanol for 30% ethanol. The collected 30% ethanol eluate was concentrated to 314 g of dry powder.

[0037] Take 100 grams of the powder and dissolve it and mix it into 400 grams of silica gel (140-180 mesh), dry it and add it to a chromatographic column with 2850 grams of the same silica gel dry-packed, and use chloroform-methanol-water (7:3:1 lower layer) The solvent system was developed ...

preparation Embodiment 2

[0060] With water 10 times the weight of the material, the white pearl of Yunnan (9 kg in weight) was reflux extracted 3 times, each time for 1 hour. Then filter the extract, concentrate the filtrate under reduced pressure at 50-65°C to a concentration of 0.5g crude drug / ml, then filter or centrifuge, and take the supernatant. The supernatant was added to the treated macroporous adsorption resin column, firstly eluted with water until the Molish reaction was negative, and then eluted with 30% ethanol. The 30% ethanol eluate was collected and concentrated to dryness under reduced pressure to obtain 362 g of the extract of the branches and leaves of Baizhu yunnanensis.

preparation Embodiment 3

[0062] First, the branches and leaves of P. yunnanensis (9 kg in weight) were reflux extracted 3 times with 50% ethanol 8 times the weight of the material, each time for 1 hour. Then filter the extract, concentrate the filtrate under reduced pressure at 50-65°C to a concentration of 0.5g crude drug / ml, then filter or centrifuge, and take the supernatant. The supernatant was added to the treated macroporous adsorption resin column, firstly eluted with water until the Molish reaction was negative, and then eluted with 30% ethanol. The 30% ethanol eluate was collected and concentrated to dryness under reduced pressure to obtain 358 g of the extract of the branches and leaves of Baizhu yunnanensis.

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Abstract

A methyltriglycosid salicylate and its preparing process, a salicylate glycoside compound and its preparing process and a medicine containing salicylate glycoside for antipyresis, relieving pain and inflammation and preventing thrombocyte coagulation are disclosed.

Description

technical field [0001] The present invention relates to a salicylate glycoside compound and a method for preparing the compound. technical background [0002] Yunnan White Pearl Gaultheria yunnanensis Rehd. It belongs to Rhododendronaceae, the roots or branches of Yunnan Baizhu tree, which is a traditional medicine of 9 ethnic groups including Bai, Dong, Lisu, Miao, Naxi, Shui, Yao, Zhuang and Buyi. It was recorded in "Southern Yunnan Materia Medica" (1459), "Chinese Ethnic Medicine Annals" and "Chinese Medicine Dictionary" in the early Ming Dynasty. Its quality standards are included in the "Quality Standards of Guizhou Traditional Chinese Medicinal Materials" (1988 edition). Dianbaizhu has the functions of clearing heat and detoxifying, promoting blood circulation and removing stasis, dispelling wind and dampness, smoothing Qi and relieving asthma. Folks are mainly used for the treatment of rheumatoid arthritis, and can also be used for the treatment of dizziness, ameno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08A61K31/7028A61P29/00A61P7/02
Inventor 丁怡杜冠华李建北张斌
Owner 丁怡
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