Novel aqueous humor drainage device for glaucoma

A technology for glaucoma and aqueous humor, applied in ophthalmic surgery, suction devices, etc., can solve problems such as filtration failure, choroidal leakage, detachment, etc., to reduce the incidence of obstruction, reduce irritation, and expand the effect of volume

Inactive Publication Date: 2006-03-22
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there may be more than 20 complications in the implantation of aqueous humor drainage. In the past, the commonly used aqueous humor drainage devices were single-tube drainage. Displacement, retraction, prolapse, postoperative low intraocular pressure, shallow anterior chamber or no anterior chamber, postoperative drainage tube blocked by blood, inflammatory debris, fibrous membrane, iris, vitreous body, etc. in the anterior chamber, resulting in filtration failure, choroid Leakage, detachment, hemorrhage and re-elevation of intraocular pressure, etc.
Although restrictive aqueous humor drainage implants can lower and maintain intraocular pressure more smoothly than non-restrictive aqueous humor drainage implants, commonly used restrictive aqueous humor drainage implants still have some structural defects

Method used

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  • Novel aqueous humor drainage device for glaucoma
  • Novel aqueous humor drainage device for glaucoma
  • Novel aqueous humor drainage device for glaucoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: as figure 1 As shown, the artificial trabecular aqueous humor drainage system consists of a T-shaped tube 1 and a drainage plate 2 connected thereto. The T-shaped tube 1 is made of a medical silicone rubber tube with an inner diameter of 0.3 mm and an outer diameter of 0.6 mm. The liquid inlet pipe 9 is about 8mm long, and the radius of curvature after bending is about 6mm. The drainage tube 10 of about 13 mm communicates. Drainage plate 2 is a pear-shaped disc structure with a length of 16mm and a width of 13mm, a height of 1.7mm, a curved spherical surface (radius of curvature 12mm), and a surface area of ​​192.2mm 2 . The drainage plate 2 of this ATDS is made of photocurable resin. The pressure control system 3 fits in the groove 4 with a height of about 0.9 mm at the front of the drainage plate 2 . Such as figure 1 As shown, the flow channel formed by this pressure control system is about 38.5mm long, with 8 elbows, 3 of which are larger than a r...

Embodiment 2

[0038] Embodiment 2: After hydrodynamic pressure test, the opening pressure of the pressure control system in the air is about 7.9~9.7mmHg (1.184±0.119kPa), and the closing pressure is about: 5.0~7.4mmHg (0.822±0.159kPa); The opening pressure in the balanced salt solution is about 7.9~9.3mmHg (1.152±0.094kPa), and the closing pressure is about: 4.9~6.0mmHg (0.791±0.143kPa); when the balanced salt solution flows at a speed of 2.5μl / min , can produce about 7.9 ~ 9.0mmHg (1.124 ± 0.075kPa) pressure difference. Therefore, the Applicant considers that the pressure control system acts as a one-way pressure sensitive valve. It can effectively control the pressure difference at both ends of the system within the required range.

Embodiment 3

[0039] Embodiment 3: animal experiments

[0040] Fifteen healthy Chinese long-eared white rabbits were implanted with artificial trabecular aqueous humor drainage device, and the intraocular pressure and anterior segment response were observed after operation. Recent observations show that the preoperative intraocular pressure of the ATDS implanted eye was 15.380±1.005mmHg, which decreased steadily within 7 days after operation, and reached the lowest level at 14 days after operation: 9.080±0.675mmHg. to 10.470±1.656mmHg, but still significantly lower than the preoperative intraocular pressure, the difference was significant (P<0.01), and there was no significant fluctuation in intraocular pressure 14, 21, and 28 days after operation. A small number of eyes had mild anterior segment reactions in the early postoperative period, such as anterior chamber flare and cellulose exudation, which disappeared within 2 to 10 days after operation, and no shallow anterior chamber, crystal ...

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Abstract

The novel aqueous humor drainage device for glaucoma consists of T-shaped pipe and draining disc connected together. The T-shaped pipe has an elastic transverse pipe with many homogeneously distributed humor inflowing holes in the aqueous humor contacting surface and a vertical pipe communicated perpendicularly with the transverse pipe and with back pressure controlling system. The draining disc has groove in the front part for the pressure controlling system, humor storing area in the back part, humor flow holes in the bottom and ridges in the center and the edge. The pressure controlling system is constituted in the extending part of the T-shaped pipe and inside the grooves of the draining disc. The aqueous humor drainage device makes the explant attached to the eyeball closely, has expanded filtering volume to reduce the stimulation to eyeball and peripheral tissue. It has good implanting operation performance, and can lower eye pressure and control eye pressure in normal range.

Description

technical field [0001] The invention relates to an ophthalmic medical device, in particular to a novel glaucoma aqueous humor drainage device, which is suitable for the treatment of glaucoma, especially some refractory glaucoma. Background technique [0002] Glaucoma is a very harmful common blinding eye disease, the incidence rate of people over 40 years old is 2%, and it accounts for the second blinding eye disease in my country. For the treatment of glaucoma, refractory glaucoma is the most difficult. Refractory glaucoma, also known as refractory glaucoma or complex glaucoma, refers to patients with high intraocular pressure who cannot be controlled by maximum tolerated drug therapy but are not suitable for filtering surgery, or who have been combined with anti-fibrotic drugs before. Glaucoma after failed surgery. Due to its various causes and complex eye conditions, the success rate of filtering surgery is only 11% to 52%. The main reason for t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/007A61M1/00
Inventor 孙乃学崔丽珺李涤尘
Owner XI AN JIAOTONG UNIV
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