Modulation of the poliovirus receptor function

A polio and virus technology, applied in the field of regulation of polio virus receptor function, can solve the problem that the physiological function of CD155/PVR has not been fully understood.

Inactive Publication Date: 2006-05-24
TUFTS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0015] However, the physiological function of CD155 / PVR is not fully understood

Method used

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  • Modulation of the poliovirus receptor function
  • Modulation of the poliovirus receptor function
  • Modulation of the poliovirus receptor function

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Embodiment approach

[0039] According to one embodiment, the PVR function modulating molecule binds to PVR, preferably but not exclusively to the extracellular part of PVR, in a specific manner, i.e. the entire receptor or at least one or more active domains thereof is controlled by The molecule is covered and therefore not available for other ligands. Accordingly, because the receptor or its active domain is covered, no receptor-mediated function can take place.

[0040] According to another embodiment, the PVR function modulating molecule binds to PVR, preferably but not exclusively to the extracellular part of PVR, in a specific manner, ie only one or more active domains of the receptor are The molecule binds and therefore cannot interact with other ligands. Accordingly, any naturally occurring receptor-mediated functions could not be induced.

[0041] According to another embodiment, said PVR function modulator molecule binds to PVR, preferably but not exclusively to the extracellular part o...

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Abstract

The present invention relates to the identification, isolation and use of molecules that interfere with functions mediated by the poliovirus receptor (PVR) on cells. The molecule can be used to treat cells with metastatic potential, metastases and cancer. The present invention further provides methods useful for identifying and isolating molecules capable of modulating PVR-mediated adhesion or invasive potential of cells.

Description

[0001] The present invention is accomplished using the CA81668 government subsidy granted by the Ministry of Health. Accordingly, the Government has certain rights in this invention. [0002] Summary [0003] The present invention relates to the identification, isolation and use of molecules that interfere with functions mediated by the poliovirus receptor (PVR) on cells. The molecule can be used to treat cells with metastatic potential, metastases and cancer. The present invention further provides methods that facilitate the identification and isolation of molecules capable of modulating PVR-mediated adhesion or invasive potential of cells. Background of the invention [0004] Cells shed by a malignant tumor can migrate to new tissue and form secondary tumors. The process by which secondary tumors develop is called metastasis, a complex process in which tumor cells are transplanted away from the primary tumor. Liotta ((1986) Cancer Res. 46, 1-7) once proposed a three-step...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28A61K31/7105A61K39/395A61K48/00A61P35/00G01N33/574
CPCY02A50/30
Inventor C·M·翁格尔G·贝斯特C·策赫特迈尔B·莱因C·托雷拉D·G·杰伊B·K·尤斯塔斯K·E·斯洛安
Owner TUFTS UNIV
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