Use of rhubard and rhubard-polysaccharide in anti-HIV

A technology of human immunodeficiency and rhubarb polysaccharides, applied in antiviral agents, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of not finding anti-HIV and incomplete research

Inactive Publication Date: 2006-05-31
SHENZHEN WU JIN QIU RES CENT OF MODERN ENG & TECH OF CHINESE MEDICINE
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Problems solved by technology

The former has not been studied in depth, and the latter has not found out specific anti-HIV substances, so the research is not thorough and only found signs of it

Method used

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Comparison scheme
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Embodiment Construction

[0016] 1. Materials: cells TC740, culture medium RPMI-1640 plus calf serum (concentration 10%), 100 U / ML (penicillin), 100 μg / ML (streptomycin) and conventional cell culture medium.

[0017] Virus: It is HIV that is activated and multiplied by TC740 cells, and the cytopathic effect is more than 75%, the concentration is 10 4-8 CID50 / 0.1ML. Emodin and rhubarb polysaccharide: the traditional Chinese medicine rhubarb was used as raw material, and the 2 Emodin and rhubarb polysaccharides are extracted by means of super-extraction.

[0018] 2. Method: cell preparation, add 2×10 3-5 100 μl / ml concentration of TC740 cells at 37°C, 50% CO 2 Incubate for 12-24 hours.

[0019] 3. Cytotoxicity test: the mixture of rhubarb and rhubarb polysaccharides was placed on the cell culture plate, and the concentration was between 1600μg / ML-25μg / ML. at 50% CO 2 Observed after 72 hours of culture in the environment.

[0020] 4. Test: (1) Control group: Add HIV on the culture plate without emo...

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Abstract

An application of emodin or emodic polyose in preparing the medicines in the form of capsule, tablet, particle, or injection for treating AIDS (HIV infection) is disclosed. Said emodin and emodic polyase are extracted from rhubarb through supercritical CO2 extraction.

Description

technical field [0001] The invention relates to the application of emodin and rheum polysaccharide, in particular to the new application of emodin and rheum polysaccharide in resisting human immunodeficiency virus (HIV). Background technique [0002] Since the first case of AIDS (AIDS) was discovered in 1981, the prevalence of AIDS has spread rapidly worldwide. Taking China as an example (as of October 2004), there are 840,000 HIV-infected people and 80,000 AIDS patients, and 160,000 deaths. people. Therefore, a climax of research on anti-HIV and treatment of AIDS drugs is spreading all over the world. But so far still have not found a drug that is both non-toxic and has no side effects, and has a better therapeutic effect to come out. [0003] Currently there are three ways to treat AIDS, one is anti-AIDS; the other is immunity; the third is anti-opportunistic infection. The first is anti-virus (HIV) therapy; the second is adjuvant therapy to improve the patient's autoim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/08A61K9/16A61K9/20A61K9/48A61K31/122A61P31/18
CPCA61K31/122A61K31/715A61K36/708A61P31/18
Inventor 杨占秋孙慧肖红
Owner SHENZHEN WU JIN QIU RES CENT OF MODERN ENG & TECH OF CHINESE MEDICINE
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