Dismutase of hydroxyamino-benzene, its coded gene, and application

Abstract

This invention describes a hydroxylamine benzene dismutase, its coding gene and applications. The hydroxylamine benzene dismutase in this invention comprises a protein from the following amino acid residue sequences: 1) SEQ ID No. 1 in the sequence table; 2) the amino acid residue sequence in SEQ ID No. 1 is a protein substituted, deleted or added with 1-10 amino acid residues and having the nitrobenzene nitro-reducing enzyme function. The hydroxylamine benzene dismutase and its coding gene in this invention play an important role in the production of ortho-aminophenols and their derivatives.

Description

technical field

[0001] The invention relates to a hydroxylamine dismutase and its encoding gene and application in the technical fields of microbial biotechnology and genetic engineering. Background technique

[0002] O-aminophenol is an intermediate in the production of dyes, medicines, and spices. It is mainly used to manufacture naphthol AS-PH, widely used in the dye industry, and also used in pharmaceutical technology and spice industries, such as: o-vanillin, etc. Therefore, with the development of printing and dyeing industry, spice industry and medical industry, the market demand for intermediates for synthesizing these products will also continue to increase. In addition, aromatic compounds have both amino groups and hydroxyl groups in adjacent positions, which can make such aromatic compounds polymerized into polymer compounds and form some molecular materials with new physical and chemical properties.

[0003] At present, the production of o-aminophenol and o-hydr...