Injection yujin frozen-dry-powder for anti-biosis and diminishing inflammation, and preparing method

An antibacterial and anti-inflammatory technology for injection, which is applied in the direction of freeze-dried delivery, antibacterial drugs, and medical preparations containing active ingredients. It can solve the problems of difficult mixing, extraction and purification, and unfavorable injections, and achieve enhanced stability. , strong pharmacological effect, and strong operability

Inactive Publication Date: 2006-08-09
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1) Yujin injection simply extracts the volatile oil components of Houttuynia cordata and honeysuckle, and discards a large number of other ingredients with antibacterial and anti-inflammatory activities, such as the active ingredient chlorogenic acid in honeysuckle, which is obviously unreasonable;
[0006] 2) The injection made of volatile oil is not easy to be mixed with other preparations clinically, causing great inconvenience;
[0007] 3) Unavoidable shortcomings such as unfavorable storage and transportation of injections, and unsuitable use under some special conditions (such as severe cold regions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation of fish gold freeze-dried powder for injection

[0021] Take 4kg of Houttuynia cordata medicinal material and moisten it with distilled water, add 32L of distilled water, collect 4L of the first distillate through steam distillation, and then carry out redistillation, collect the distillate to obtain 500ml of Houttuynia cordata water distillate, drop by drop the Houttuynia cordata water distillate Add 20% hydroxypropyl-β-cyclodextrin solution to 2000ml, cut with a high-speed shearing machine during the addition process, and clathrate for 8 hours to obtain the cyclodextrin clathrate solution of Houttuynia cordata water distillate.

[0022] Take 2kg honeysuckle medicinal material and decoct twice with water, add 20L deionized water each time and decoct for 2 hours, combine the two water extracts and concentrate under reduced pressure to a relative density between 1.15-1.20 (50°C) (measured value 1.18), continuously Add 95% medicinal ethanol under...

Embodiment 2

[0024] Embodiment 2: Preparation of fish gold freeze-dried powder for injection

[0025] Take 4kg Houttuynia cordata medicinal material and moisten it with distilled water, add 28L distilled water, collect 4L initial distillate through steam distillation, and then carry out redistillation, collect the distillate to obtain 500ml Houttuynia cordata hydrodistillate, drop by drop the Houttuynia cordata hydrodistillate Add 20% hydroxypropyl-β-cyclodextrin solution to 2000ml, cut with a high-speed shearing machine during the addition process, and clathrate for 10 hours to obtain the cyclodextrin clathrate solution of Houttuynia cordata water distillate.

[0026] Take 2kg honeysuckle medicinal material and decoct twice with water, add 20L deionized water each time and decoct for 2 hours, combine the two water extracts and concentrate under reduced pressure to a relative density between 1.15-1.20 (50°C) (measured value 1.15), continuously Add 95% medicinal ethanol under stirring to ad...

Embodiment 3

[0028] Embodiment 3: Preparation of fish gold freeze-dried powder for injection

[0029] Take 4kg of Houttuynia cordata medicinal material and moisten it with distilled water, add 24L of distilled water, collect 4L of the first distillate through steam distillation, and then carry out redistillation, collect the distillate to obtain 500ml of Houttuynia cordata water distillate, drop by drop the Houttuynia cordata water distillate Add 20% hydroxypropyl-β-cyclodextrin solution to 2000ml, cut with a high-speed shearing machine during the addition process, and clathrate for 6 hours to obtain the cyclodextrin clathrate solution of Houttuynia cordata hydrodistillate.

[0030] Take 2kg honeysuckle medicinal material and decoct twice with water, add 20L deionized water each time and decoct for 2 hours, combine the two water extracts and concentrate under reduced pressure to a relative density between 1.15-1.20 (50°C) (measured value 1.16), continuously Add 95% medicinal ethanol under ...

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PUM

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Abstract

The present invention relates to an Yujin freeze-dried powder for injection. Said freeze-dried powder injection has the functions of resisting bacteria and relieving inflammation, and can be used fro effectively curing the diseases of upper respiratory tract infection, bronchopneumonia, virus pneumonia, pyogenic disease and gynecological inflammation, etc. with obvious therapeutic effect. Said freeze-dried powder for injection is formed from houttuynia extract powder, lonicera flower extract powder and proper auxiliary material through a certain preparation process.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine injections for antibacterial and anti-inflammatory, and relates to a freeze-dried fish gold powder for injection and a preparation method thereof. Background technique: [0002] Houttuynia cordata is a common medicinal material in traditional Chinese medicine. It is a plant of the family Sanbaiaceae. It is widely distributed in the southern provinces of my country. It has been studied as an edible and medicinal plant since the beginning of the 20th century. Modern research shows that Houttuynia cordata contains 0.018% volatile oil. -0.036%, its main volatile oil components are houttuyfonate, methylnonanone, myrcene, lauric aldehyde, calyxanic acid, etc. houttuyonin has strong antibacterial effect, and there is development of houttuynia cordata injection in my country , has the effect of clearing away heat, detoxifying, and promoting dampness. It is used for lung abscess, phlegm-heat coug...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/19A61P31/04A61P11/04
Inventor 王伟
Owner 广东仁泰药业有限公司
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