Method for preparing high-content troxerutin drug

Abstract

The invention offers 3', 4', 7-troxerutin synthetic method. It uses rutin and ethylene oxide to do hydroxyethylation reaction under the catalyzing of sodium hydroxide. Its features are that in the reaction, the weight ratio of rutin and water is 1:1-1:3; optimization is 1:1-1:1.5; the weight ratio of rutin and sodium hydroxide is 100:0.82-100:0.85; adding resin when the pH value of the reaction solution is 9.0-9.5 to adjust end point pH value to 9.5-10.3. The method can make high purity and high quality troxerutin. And its 3', 4', 7-troxerutin content is more than 78%; optimization is more than 80%; and the more optimization is more than 85%.

Description

technical field

[0001] The invention belongs to the field of chemical pharmacy, in particular, the invention relates to a preparation method of troxerutin medicine with high content. Background technique

[0002] The chemical name of Troxerutin is: 3', 4', 7-tri[O-(2-hydroxyethyl)] rutin, referred to as 3', 4', 7-trihydroxyethyl rutin Ding, a water-soluble product obtained by hydroxyethylation of rutin, has better absorption and better curative effect than rutin, can reduce capillary permeability and fragility, improve capillary resistance, inhibit Platelet aggregation, prevention of thrombosis, etc., can be used to treat hemiplegia, aphasia, arteriosclerosis, varicose veins, central retinitis, pre-myocardial infarction syndrome, and edema caused by increased vascular permeability caused by cerebral thrombosis and cerebral embolism and other diseases, especially in the prevention of arteriosclerosis has a good effect.

[0003] CN1056850C discloses a method for synthesizing...

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