A probiotic composition comprising at least two lactic acid bacterial strains which are able to colonise the gastrointestinal tracts in combination with having intestinal survival property, intestinal

A technology of protection characteristics and probiotics, applied in the direction of bacteria used in food preparation, medical preparations containing active ingredients, Lactobacillus, etc., can solve the problems of inability to survive, temporarily settle, and not adhere to the colon mucosa.

Inactive Publication Date: 2006-08-16
生物合成公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most commercially available probiotics do not survive the stomach acid or the bile acid content of the small intestine, and they do not attach to the colonic mucosa, nor do they even temporarily colonize the stomach

Method used

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Examples

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Embodiment Construction

[0022] All LAB-strains of different species were grown aerobically on MRS agar at 37°C for 24 hours. In further experiments, growth at different temperatures was determined. All strains can reproduce at temperatures from +4°C to 40°C or 45°C. All strains produced protease as determined by skim milk agar assay (24 hours, aerobic, 37°C). None of the strains produced nitrite or nitrate.

[0023] All LAB-strains of different species could utilize prebiotics, such as inulin and pullulan, but not β-glucose, as determined by growth on YNB medium utilizing fibers such as prebiotics as the sole carbon source. glycans. Since the strains are able to ferment these fibers, they will play a beneficial role in the colonic flora. Enhanced fiber degradation also increases crude fiber digestibility.

[0024] In the composition of the invention, a mixture of cocci and bacilli is optimal because cocci and bacilli have different generation times and bacilli proliferate much faster than cocci....

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Abstract

In a probiotic composition comprising at least two specific lactic acid bacterial strains, the strains are able to colonize the gastrointestinal tract of humans and animals and have in combination at least two beneficial properties. The properties include an intestinal survival property, an intestinal binding property, an infection protecting property, and a fiber fermenting property.

Description

technical field [0001] The present invention relates to a new probiotic composition. More specifically, the present invention relates to a probiotic composition comprising at least two strains of lactic acid bacteria having at least two notable properties of maintaining the intestinal microbial ecosystem, preventing and treating gastrointestinal disorders and being able to colonize the gastrointestinal tract . Background technique [0002] The gut flora comprises approximately 95% of the total number of cells in the human body. The importance of the gut microbiota, and more specifically its composition, in the physiology as well as the pathophysiology of the adult gastrointestinal tract has become increasingly apparent. [0003] Health effects associated with altered gut microflora are attributed to live microorganisms (bacteria or yeast) that have a beneficial effect on the health of the host. The presence of lactic acid bacteria has been found to be important for mainta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/127A61K35/74A23L1/03A61P1/00A23K1/00A23L1/30A23L29/00A61K35/744A61K35/747
CPCA23K1/009A61K35/747A23Y2220/67A23Y2280/55A23L1/3014A23L1/0345A61K35/744A23Y2260/35A23K10/18A23L29/065A23L33/135A61P1/00A61P1/14A61P31/04A61P31/10A61P43/00A23V2400/321A23V2400/427A23V2400/169
Inventor A·荣-瓦德斯特伦T·瓦德斯特伦S·本格马克
Owner 生物合成公司
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