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Prulifloxacin compound preparation

A technology of prulifloxacin and compound preparations, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve good synergistic effect, uniform distribution, and wide application range

Inactive Publication Date: 2006-09-27
夏中宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report that prulifloxacin and pidotimod are used in combination to treat bacterial infectious diseases. The inventor has carried out research and a large number of tests on the synergistic effect of the combined application of these two drugs, and finally obtained the present invention.

Method used

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  • Prulifloxacin compound preparation
  • Prulifloxacin compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prulifloxacin 200g

[0021] Pidotimod 800g

[0022] Starch 200g

[0023] Microcrystalline Cellulose 250g

[0024] Low-substituted hydroxypropyl cellulose 80g

[0025] Hydroxypropyl Cellulose 80g

[0026] Microcrystalline cellulose (external) 50g

[0027] Magnesium stearate (external) 12g

[0028] 40% ethanol appropriate amount

[0029] Tablet made 1000 capsules

[0030] Its preparation method is:

[0031] (1) Pass each raw material and auxiliary material through a 100-mesh sieve

[0032] (2) Granulation

[0033] ① Add the excipients added in the prescription amount into the mixer, and dry mix for 10 minutes;

[0034] ② Add an appropriate amount of 40% ethanol to the mixed raw and auxiliary materials, mix to make a soft material, and granulate with a 36-mesh sieve;

[0035] ③ Dry the granules at about 60 degrees Celsius, add the prescribed amount of additional auxiliary materials, mix well, and sieve the granules with a 36-mesh sieve;

[0036] (3) It can be o...

Embodiment 2

[0039] Take 200g of prulifloxacin, 800g of pidotimod, Tween 8015.5g, and 90g of mannitol, add 2000ml of water for injection to dissolve them all, add 1% activated carbon to depyrogenate, pass through a 0.22μm microporous membrane, and pack in 1000 Support in 10ml vials, freeze-dry to get injection powder.

[0040] The following examples are all expressed as active ingredients.

Embodiment 3

[0041] Example 3: prulifloxacin 50 mg; pidotimod 200 mg.

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PUM

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Abstract

The compound prulifloxicin preparation is used in treating bacterial infectious diseases. The compound prulifloxicin preparation consists of prulifloxicin 50-600 mg, pidaomode 200-1600 mg and pharmaceutically acceptable supplementary material, and is prepared into various pharmaceutically acceptable preparation forms for treating bacterial infectious diseases clinically. It can raise bodyí»s immunity level to strengthen the exogenous bactericidal effect of prulifloxicin.

Description

technical field [0001] The invention relates to a prulifloxacin compound preparation for treating bacterial infectious diseases. Background technique [0002] Prulifloxacin (Prulifloxacin) is a fourth-generation quinolone antibacterial drug developed by Japan New Drug Company. Its chemical name is: 6-fluoro-1-methyl-7-[4-(5-methyl-2- Oxo-1,3-dioxol-4-yl)methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazetidine[3, 2-a] Quinoline-3-carboxylic acid, molecular formula: C 21 h 20 FN 3 o 6 S, molecular weight: 461.46. Prulifloxacin has excellent pharmacokinetic and pharmacodynamic characteristics, broad antibacterial spectrum, few side effects, and is not easy to develop drug resistance. It has good curative effect in clinical treatment of bacterial infections. However, in recent years, due to the increase of bacterial resistance due to the extensive use of antibiotics, the clinical treatment of bacterial infections has been plagued by problems such as complexity, refractory and repe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/20A61K9/48A61K9/08A61K9/14A61P31/04
Inventor 刘全胜夏中宁舒军林学良
Owner 夏中宁
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